Zhou Z, He S, Liang Y
Department of Ophthalmology, No. 304 Hospital, Beijing.
Zhonghua Yan Ke Za Zhi. 1996 Nov;32(6):421-3.
To study the pathological changes and morphological features in the iris and ciliary body after lens extraction and intraocular lens (IOL) implantation in rabbits and discuss the mechanism of postoperative intraocular inflammatory response.
27 adult pigmented rabbits were divided into three groups, (1) extracapsular lens extraction and IOL implantation. (2) simple extracapsular lens extraction, and (3) the control group without surgical intervention. The iris and ciliary body in every eye were taken on the 1st, 7th and 14th days after surgery, their pathological changes were observed with light microscopy, and the number of inflammatory cells were counted. The data were analyzed by using analysis of variance of SAS software.
The pathological changes might be divided into three stages: (1) acute inflammation and exudative changes in the early stage (on the 1st day postoperatively), (2) subacute inflammation and granuloma formation in the middle stage (on the 7th day postoperatively, and (3) chronic inflammation and fibrosis in the late stage (on the 14th day postoperatively).
The inflammatory cells in the iris and ciliary body are significantly higher in eyes with IOL implantation than that in eyes with simple extracapsular lens extraction (P < 0.01). Besides macrophages, there are many lymphocytes, eosinophils and plasma cells in the iris and ciliary body, suggesting that an active immune response exist in the inflammation.
研究兔晶状体摘除及人工晶状体（IOL）植入术后虹膜和睫状体的病理变化及形态学特征，探讨术后眼内炎症反应的机制。
将27只成年有色兔分为三组，（1）晶状体囊外摘除及IOL植入组。（2）单纯晶状体囊外摘除组，（3）未进行手术干预的对照组。于术后第1天、第7天和第14天取每只眼的虹膜和睫状体，用光镜观察其病理变化，并计数炎症细胞数量。采用SAS软件进行方差分析对数据进行分析。
病理变化可分为三个阶段：（1）早期（术后第1天）急性炎症和渗出性改变，（2）中期（术后第7天）亚急性炎症和肉芽肿形成，（3）后期（术后第14天）慢性炎症和纤维化。
植入IOL的眼内虹膜和睫状体中的炎症细胞明显高于单纯晶状体囊外摘除的眼（P<0.01）。除巨噬细胞外，虹膜和睫状体中还有许多淋巴细胞、嗜酸性粒细胞和浆细胞，提示炎症中存在活跃的免疫反应。
