Redmond A F, Cherry D V, Bowers D E
Department of Applied Dental Medicine, School of Dental Medicine, Southern Illinois University-Edwardsville, Alton 62002-4798, USA.
Am J Dent. 1997 Dec;10(6):268-71.
To determine whether ingestion of a tooth whitener containing 6% hydrogen peroxide as bleaching agent affected the gastric mucosa of adult, female laboratory rats.
Thirty-six fasting rats were intubated with a single bolus (5 g/kg body weight) of the tooth whitener Natural White which contains 6% hydrogen peroxide. Thirty-two control rats received deionized water. Rats were necropsied 15 minutes, 2 hours, 1 and 2 weeks after whitener ingestion. The gastric mucosa was examined histologically and blood hematocrit, glucose, BUN, and bilirubin measured.
Six of the 36 rats died within 2 hours of receiving whitener. Within 15 minutes of whitener ingestion, stomachs were grossly bloated with gas. Histological observation showed that gastric mucosal cells were vacuolated and gastric glands dilated. After 2 hours, gastric epithelial and glandular cells had sloughed off into the gastric lumen. Mean blood glucose and hematocrit were significantly (P < 0.05) elevated (233 +/- 41 mg/ml and 50.5 +/- 0.9%) over mean control values (129 +/- 8 mg/ml and 42.8 +/- 2.4%). Within 1 week, the stomachs of experimental rats were no longer bloated, the gastric mucosa appeared normal histologically, but mean blood hematocrit was significantly (P < 0.05) decreased (38.0 +/- 1.5%) from mean control value (43.3 +/- 0.5%). There were no significant differences in mean blood values 2 weeks after whitener ingestion.
确定摄入含有6%过氧化氢作为漂白剂的牙齿美白剂是否会影响成年雌性实验大鼠的胃黏膜。
36只禁食大鼠经插管一次性给予一剂（5克/千克体重）含有6%过氧化氢的牙齿美白剂Natural White。32只对照大鼠给予去离子水。在摄入美白剂后15分钟、2小时、1周和2周对大鼠进行尸检。对胃黏膜进行组织学检查，并测量血液中的血细胞比容、葡萄糖、尿素氮和胆红素。
36只大鼠中有6只在摄入美白剂后2小时内死亡。摄入美白剂后15分钟内，胃部明显胀气。组织学观察显示胃黏膜细胞出现空泡化，胃腺扩张。2小时后，胃上皮细胞和腺细胞脱落至胃腔。平均血糖和血细胞比容显著（P<0.05）高于平均对照值（分别为233±41毫克/毫升和50.5±0.9%，对照值分别为129±8毫克/毫升和42.8±2.4%）。1周内，实验大鼠的胃部不再胀气，胃黏膜组织学外观正常，但平均血细胞比容较平均对照值显著（P<0.05）降低（38.0±1.5%，对照值为43.3±0.5%）。摄入美白剂2周后血液各项均值无显著差异。
