前列腺素F2α对外源性哮喘肺力学的影响。
Effect of prostaglandin F2 alpha on lung mechanics in extrinsic asthma.
作者信息
Patel K R
出版信息
Postgrad Med J. 1976 May;52(607):275-8. doi: 10.1136/pgmj.52.607.275.
In normal subjects inhalation of PGFα produced two qualitatively different airways responses. In five subjects there was a significant fall in SG without change in maximum expiratory flow rates, FEV or CV. In contrast, the remaining three subjects showed a significant fall in flow rates and FEV together with a significant increase in CV while their SG was unaffected. PGFα inhalation in six asthmatic patients produced a significant fall in maximum expiratory flow rates, FEV and SG. These patients showed a dual response with individual variability in magnitudes of changes. It is suggested that differing responses may reflect the balance between the sympathetic and parasympathetic nervous controls of the airways, and that the diminished β-receptor activity in asthmatic patients may account for heightened bronchoconstrictor response to inhaled PGFα both centrally and peripherally in the bronchial tree.
在正常受试者中，吸入前列腺素Fα（PGFα）会产生两种性质不同的气道反应。在五名受试者中，气道特异性传导率（SG）显著下降，而最大呼气流量、第一秒用力呼气容积（FEV）或比气道传导率（CV）无变化。相比之下，其余三名受试者的流量和FEV显著下降，CV显著增加，而其SG未受影响。六名哮喘患者吸入PGFα后，最大呼气流量、FEV和SG显著下降。这些患者表现出双重反应，变化幅度存在个体差异。提示不同的反应可能反映了气道交感神经和副交感神经控制之间的平衡，哮喘患者β受体活性降低可能是支气管树中央和外周对吸入PGFα支气管收缩反应增强的原因。
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