Van Rompay K K, Berardi C J, Dillard-Telm S, Tarara R P, Canfield D R, Valverde C R, Montefiori D C, Cole K S, Montelaro R C, Miller C J, Marthas M L
California Regional Primate Research Center, Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis 95616-8542, USA.
J Infect Dis. 1998 May;177(5):1247-59. doi: 10.1086/515270.
To determine if passively acquired antiviral antibodies modulate virus transmission and disease progression in human pediatric AIDS, the potential of pre- and postexposure passive immunization with hyperimmune serum to prevent oral simian immunodeficiency virus (SIV) infection or disease progression in newborn rhesus macaques was tested. Untreated neonates became infected after oral SIV inoculation and had high viremia, and most animals developed fatal AIDS within 3 months. In contrast, SIV hyperimmune serum given subcutaneously prior to oral SIV inoculation protected 6 newborns against infection. When this SIV hyperimmune serum was given to 3 newborns 3 weeks after oral SIV inoculation, viremia was not reduced, and all 3 infants died within 3 months of age due to AIDS and immune-complex disease. These results suggest that passively acquired antihuman immunodeficiency virus (HIV) IgG may decrease perinatal HIV transmission. However, anti-HIV IgG may not impart therapeutic benefit to infants with established HIV infection.
为了确定被动获得的抗病毒抗体是否能调节人类儿童艾滋病中病毒的传播和疾病进展,我们测试了用超免疫血清进行暴露前和暴露后被动免疫预防新生恒河猴口腔感染猿猴免疫缺陷病毒(SIV)或疾病进展的可能性。未经治疗的新生儿在口服SIV接种后被感染,病毒血症水平很高,大多数动物在3个月内发展为致命的艾滋病。相比之下,在口服SIV接种前皮下注射SIV超免疫血清可保护6只新生猴免受感染。当在口服SIV接种3周后给3只新生猴注射这种SIV超免疫血清时,病毒血症并未降低,所有3只婴儿在3个月龄内死于艾滋病和免疫复合物疾病。这些结果表明,被动获得的抗人类免疫缺陷病毒(HIV)IgG可能会减少围产期HIV传播。然而,抗HIV IgG可能不会给已感染HIV的婴儿带来治疗益处。