结核分枝杆菌对阿米卡星和卡那霉素的耐药机制
Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis.
作者信息
Alangaden G J, Kreiswirth B N, Aouad A, Khetarpal M, Igno F R, Moghazeh S L, Manavathu E K, Lerner S A
机构信息
Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
出版信息
Antimicrob Agents Chemother. 1998 May;42(5):1295-7. doi: 10.1128/AAC.42.5.1295.
Abstract
An A1400G mutation of the rrs gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical isolates resistant to amikacin-kanamycin (MICs, >128 microg/ml). High-level cross-resistance may result from such a mutation since MTB has a single copy of the rrs gene. Another mechanism(s) may account for high-level amikacin-kanamycin resistance in two mutants and lower levels of resistance in four clinical isolates, all lacking the A1400G mutation.
摘要
在结核分枝杆菌（MTB）菌株ATCC 35827以及13株对阿米卡星-卡那霉素耐药（最低抑菌浓度，>128μg/ml）的MTB临床分离株中，鉴定出rrs基因的A1400G突变。由于MTB只有rrs基因的单拷贝，这种突变可能导致高水平交叉耐药。另外的机制可能解释了两个突变体中高水平的阿米卡星-卡那霉素耐药以及四个临床分离株中较低水平的耐药，这些菌株均不存在A1400G突变。
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