The use of high-throughput synthesis and purification in the preparation of a directed library of adrenergic agents.
作者信息
Siegel M G, Shuker A J, Droste C A, Hahn P J, Jesudason C D, McDonald J H, Matthews D P, Rito C J, Thorpe A J
机构信息
Research Technology & Proteins, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.
出版信息
Mol Divers. 1997;3(2):113-6. doi: 10.1023/a:1009602403514.
PMID:9593180
Abstract
A library of potential agonists and antagonists for adrenergic receptors was prepared using high-throughput solution-phase parallel synthesis. Traditional solution-phase reductive amination reactions followed by rapid purification by ion exchange chromatography yielded products with near-analytical purity. An array of ketones and amines, arranged in an 8 x 12 matrix, were combined to form 96 individual compounds.
摘要
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