Ursea R, Coleman D J, Silverman R H, Lizzi F L, Daly S M, Harrison W
Department of Ophthalmology, Cornell University Medical College, New York, New York 10021, USA.
Ophthalmology. 1998 May;105(5):906-12. doi: 10.1016/S0161-6420(98)95036-9.
This study aimed to correlate histologic characteristics with high-frequency ultrasound backscatter spectra in malignant melanomas of the iris.
The study design was a cohort (case series) study of patients diagnosed with iris melanoma in the authors' clinic.
Sixteen patients with iris melanoma participated.
The patients were scanned with a 50-MHz ultrasound unit equipped for digitization of raw echo data. Spectral parameter images representing the spatial distribution of size and concentration of tissue inhomogeneities were produced.
The variation of spectral properties within and between tumors was determined. In the two tumors in this series for which histologic material was available, the authors compared scatterer concentration and size with histology and mathematically modeled the effect of melanocyte distribution on spectra.
Ultrasound scattering characteristics differed considerably among tumors. Where histology was available, acoustic parameters correlated with the size and number of melanocytes present.
Iris melanomas exhibited a wide range in acoustic backscatter properties. Whereas characteristics such as vascularity and necrosis might contribute to this, in the two cases examined here, backscatter characteristics could be largely accounted for by melanocyte distribution. A better understanding of the relationship of histology to noninvasive ultrasound data will enhance the diagnostic utility of this technique.
本研究旨在探讨虹膜恶性黑色素瘤的组织学特征与高频超声背向散射光谱之间的相关性。
本研究为队列（病例系列）研究，研究对象为作者诊所诊断为虹膜黑色素瘤的患者。
16例虹膜黑色素瘤患者参与研究。
使用配备原始回波数据数字化功能的50兆赫超声设备对患者进行扫描。生成代表组织不均匀性大小和浓度空间分布的光谱参数图像。
确定肿瘤内部和肿瘤之间光谱特性的变化。在本系列中有组织学材料的两个肿瘤中，作者将散射体浓度和大小与组织学进行比较，并对黑素细胞分布对光谱的影响进行数学建模。
不同肿瘤的超声散射特征差异很大。在有组织学资料的情况下，声学参数与黑素细胞的大小和数量相关。
虹膜黑色素瘤的声学背向散射特性范围很广。血管形成和坏死等特征可能对此有影响，而在本研究的两例病例中，背向散射特征在很大程度上可由黑素细胞分布来解释。更好地理解组织学与无创超声数据之间的关系将提高该技术的诊断效用。
