一氧化氮对发育中大鼠癫痫发作活动的年龄依赖性调节

Age-dependent regulation of seizure activity by nitric oxide in the developing rat.

作者信息

Pereira de Vasconcelos A, Marescaux C, Nehlig A

机构信息

INSERM 398, Faculté de Médecine, 11 rue Humann, 67085 Strasbourg Cédex, France.

出版信息

Brain Res Dev Brain Res. 1998 May 15;107(2):315-9. doi: 10.1016/s0165-3806(98)00035-2.

DOI:10.1016/s0165-3806(98)00035-2

PMID:9593965

Abstract

The role of nitric oxide (NO) on the age-dependent selective vulnerability to the consequences of epileptic seizures was studied in 10-day old (P10) and 21-day old (P21) rats. At P10, the NO synthase (NOS) inhibitor, NG-nitro-l-arginine (LNA), increased severity of seizures while l-arginine (l-Arg), the NOS substrate, had no effect. At P21, l-Arg improved the outcome of seizures while LNA had no effect. These results demonstrated the age-dependent role of NO in epilepsy.

摘要

在10日龄（P10）和21日龄（P21）的大鼠中研究了一氧化氮（NO）在癫痫发作后果的年龄依赖性选择性易损性中的作用。在P10时，NO合酶（NOS）抑制剂NG-硝基-L-精氨酸（LNA）增加了癫痫发作的严重程度，而NOS底物L-精氨酸（L-Arg）则没有作用。在P21时，L-Arg改善了癫痫发作的结果，而LNA则没有作用。这些结果证明了NO在癫痫中具有年龄依赖性作用。