Yeghiayan S K, Gongwer M A, Baldessarini R J, Kula N S, Zong R, Neumeyer J L
Consolidated Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA.
Brain Res. 1998 May 11;792(2):324-6. doi: 10.1016/s0006-8993(98)00202-9.
N-chloroethyl derivatives of 7-hydroxy-1,2,3,4-tetrahydronaphthalene (7-OH-DPAT), 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ), or fluphenazine were microinjected into rat nucleus accumbens (Acc), and receptor binding quantified autoradiographically after 24 h. EEDQ reduced [3H]nemonapride (D2-like receptors) binding in Acc (by 84%) and islands of Calleja (IC; 44%), without affecting 3H-7-OH-DPAT (D3); N-chloroethyl-7-OH-DPATs blocked both radioligands in Acc and IC (30%-70%); fluphenazine had no effect.
将7-羟基-1,2,3,4-四氢萘（7-OH-DPAT）、1-乙氧羰基-2-乙氧基-1,2-二氢喹啉（EEDQ）或氟奋乃静的N-氯乙基衍生物微量注射到大鼠伏隔核（Acc）中，24小时后通过放射自显影法定量受体结合。EEDQ降低了Acc中[3H]奈莫必利（D2样受体）的结合（降低84%）以及Calleja岛（IC；降低44%），而不影响3H-7-OH-DPAT（D3）；N-氯乙基-7-OH-DPATs阻断了Acc和IC中两种放射性配体（30%-70%）；氟奋乃静无作用。
