Milos N C, Meadows G, Evanson J E, Pinchbeck J B, Bawa N, Young K J, Palmer N G, Murdoch C A, Carmel D
Department of Oral Health Sciences, University of Alberta, Edmonton, Canada.
J Craniofac Genet Dev Biol. 1998 Jan-Mar;18(1):11-29.
Cranial neural crest of Xenopus laevis at different stages of development from neurulation to metamorphosis was studied for the expression of the endogenous galactoside-binding lectin of Xenopus using immunocytochemistry. The presence and localization of members of the N-CAM and cadherin cell adhesion families were also investigated. Lectin and the other known cell adhesion molecules are expressed throughout development and their localization patterns change coordinately depending on the development stage. All the molecules colocalize. The results suggest that all of these molecules, including the lectin, may be involved in cranial development, possibly in cellular adhesion.
利用免疫细胞化学方法，研究了非洲爪蟾从神经胚形成到变态发育不同阶段的颅神经嵴中非洲爪蟾内源性半乳糖苷结合凝集素的表达情况。同时还研究了N-CAM和钙黏蛋白细胞黏附家族成员的存在及定位。凝集素和其他已知的细胞黏附分子在整个发育过程中均有表达，并且它们的定位模式会根据发育阶段而协同变化。所有这些分子都共定位。结果表明，所有这些分子，包括凝集素，可能都参与颅部发育，可能与细胞黏附有关。
