Suzuki H, Ogawa S, Hanaoka K, Kugimiya T, Yokoyama K, Isshiki A, Hosoyamada A, Kikuchi H, Numata K
Department of Anesthesiology, Nihon University Surugadai Hospital, Tokyo.
Masui. 1998 Apr;47(4):447-65.
Spinal anesthesia with two types of 0.5% bupivacaine hydrochloride solution, isobaric AJ-007 I and hyperbalic AJ-007 H, was studied clinically in 106 surgical patients with collaboration of 7 university hospitals. The following results were obtained. 1) Successful analgesia with motor block on abdominal wall and legs could be induced by dosages of 2.0 ml, 3.0 ml and 4.0 ml of either of the two solutions. 2) With isobaric solutions, the duration of the block was prolonged dose dependently. Anesthetic levels tended to increase and onset times of the block tended to decrease, with increasing dosage. 3) Hyperbalic solutions tended to produce higher levels of the block more rapidly. However, the duration of the block seemed to be shorter than that achieved by isobaric solutions. 4) The incidence of hypotension and bradycardia was similar to that observed in ordinary clinical spinal anesthesia. In one young male, a high level (C 2) of anesthesia was achieved after administration of 4.0 ml of hyperbaric solution. This patient was managed uneventfully under general anesthesia during the surgery. These results indicate that these two solutions of 0.5% bupivacaine are useful for spinal anesthesia.
在7家大学医院的协作下，对106例外科手术患者进行了临床研究，使用了两种0.5%盐酸布比卡因溶液：等比重AJ - 007 I和重比重AJ - 007 H进行脊髓麻醉。获得了以下结果。1）两种溶液中的任何一种，剂量为2.0毫升、3.0毫升和4.0毫升时，均可诱导出成功的镇痛效果，并伴有腹壁和腿部的运动阻滞。2）使用等比重溶液时，阻滞持续时间呈剂量依赖性延长。随着剂量增加，麻醉平面趋于升高，阻滞起效时间趋于缩短。3）重比重溶液往往能更快地产生更高的麻醉平面。然而，阻滞持续时间似乎比等比重溶液短。4）低血压和心动过缓的发生率与普通临床脊髓麻醉中观察到的相似。在一名年轻男性患者中，给予4.0毫升重比重溶液后达到了高位（C2）麻醉。该患者在手术期间在全身麻醉下顺利处理。这些结果表明，这两种0.5%布比卡因溶液可用于脊髓麻醉。
