Hisakane M, Katayama Y, Igarashi H, Terashi A
Second Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
Nihon Ika Daigaku Zasshi. 1998 Apr;65(2):135-9. doi: 10.1272/jnms1923.65.135.
The superacute stage of focal ischemia can be visualized using T2-weighted MRI following the injection of superparamagnetic iron oxide particles (magnetite). In this study we evaluated the optimal time point, i.e. the time producing the strongest signal, for the injection of magnetite using T2-weighted MRI following left parmanent middle cerebral artery occlusion (lt.-PMCAO). Male Sprague-Dawley rats were anesthetized and the left middle cerebral artery (lt.-MCA) was permanently occluded. Magnetite was then injected into the femoral vein after 20 to 30 min of lt.-PMCAO. T2-weighted MR images were taken immediately, and 15 and 30 min after magnetite injection. A high signal area at the region of the lt.-MCA was clearly seen on the T2-weighted MRI immediately after magnetite injection. However, it became less clear after 15 min, and by 30 min could not be distinguished. These results suggest that magnetite should be injected immediately prior to T2-weighted MR imaging during the superacute stage of focal ischemia.
在注射超顺磁性氧化铁颗粒（磁铁矿）后，使用T2加权磁共振成像（MRI）可以观察到局灶性缺血的超急性期。在本研究中，我们评估了在左侧大脑中动脉永久性闭塞（lt.-PMCAO）后，使用T2加权MRI注射磁铁矿的最佳时间点，即产生最强信号的时间。雄性Sprague-Dawley大鼠麻醉后，左侧大脑中动脉（lt.-MCA）被永久性闭塞。在lt.-PMCAO 20至30分钟后，将磁铁矿注入股静脉。在注入磁铁矿后立即、15分钟和30分钟拍摄T2加权MR图像。注入磁铁矿后立即在T2加权MRI上清楚地看到lt.-MCA区域的高信号区。然而，15分钟后它变得不那么清晰，到30分钟时无法区分。这些结果表明，在局灶性缺血超急性期，应在T2加权MR成像之前立即注射磁铁矿。
