箭毒化大鼠的下丘脑化学刺激与自主神经变化

Hypothalamic chemostimulation and autonomic changes in curarized rats.

作者信息

Carmona A, Slangen J

出版信息

Psychopharmacology (Berl). 1976 May 5;47(1):105-10. doi: 10.1007/BF00428711.

Abstract

Rats previously implanted with chronic double walled cannulae aimed at the lateral hypothalamic area (LHA) ate and drank reliably after minute injections of norepinephrine and carbachol respectively. Later on the rats were curarized and artificially respirated. After an habituation period during which rectal temperature, cardiac rate and peripheral vasomotor activity were continuously recorded, half of the subjects were injected with 1 mul of norepinephrine (40 x 10(-9) moles) and the other half with 1 mul of carbachol (2.4 x 10(-9)moles). Both drugs elicited hypothermia, bradycardia and vasodilatation. Bradycardia after carbachol was significantly greater than after norepinephrine and hypothermia and vasodilatation after norepinephrine were significantly greater than after carbachol. When the treatments were reversed essentially the same effects were observed.

摘要

先前植入了旨在靶向下丘脑外侧区（LHA）的慢性双壁套管的大鼠，在分别微量注射去甲肾上腺素和卡巴胆碱后，可靠地出现了进食和饮水行为。随后对大鼠进行箭毒麻痹并实施人工呼吸。在一个适应期内持续记录直肠温度、心率和外周血管舒缩活动，之后，一半的实验对象被注射1微升去甲肾上腺素（40×10⁻⁹摩尔），另一半被注射1微升卡巴胆碱（2.4×10⁻⁹摩尔）。两种药物均引发体温过低、心动过缓和血管舒张。卡巴胆碱引发的心动过缓显著大于去甲肾上腺素引发的，而去甲肾上腺素引发的体温过低和血管舒张显著大于卡巴胆碱引发的。当处理方式颠倒时，观察到了基本相同的效果。