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巴比妥对大鼠中枢神经系统对己巴比妥敏感性的影响。

Barbital alteration of central nervous system sensitivity to hexobarbital in the rat.

作者信息

Schnell R C, Stoll R E, Prosser T D

出版信息

Psychopharmacology (Berl). 1976 May 5;47(1):93-6. doi: 10.1007/BF00428708.

DOI:10.1007/BF00428708
PMID:959468
Abstract

Alteration in central nervous system (CNS) sensitivity to the hypnotic effect of the hexobarbital was assessed by analytical, electroencephalographic, and pharmacokinetic techniques in barbital-treated rats. Each of these conceptually diverse experimental methodologies yielded similar conclusions concerning the alteration of CNS sensitivity by barbital treatment.

摘要

通过分析、脑电图和药代动力学技术，评估了在巴比妥治疗的大鼠中，中枢神经系统（CNS）对己巴比妥催眠作用的敏感性变化。这些概念上不同的实验方法，每一种都得出了关于巴比妥治疗引起的CNS敏感性变化的相似结论。

相似文献

1
Barbital alteration of central nervous system sensitivity to hexobarbital in the rat.巴比妥对大鼠中枢神经系统对己巴比妥敏感性的影响。
Psychopharmacology (Berl). 1976 May 5;47(1):93-6. doi: 10.1007/BF00428708.
2
Similarity in cns sensitivity to hexobarbital in the rat and mouse as determined by an analytical, a pharmacokinetic, and an electroencephalographic measure.通过分析、药代动力学和脑电图测量确定大鼠和小鼠中枢神经系统对己巴比妥敏感性的相似性。
Pharmacology. 1975;13(1):20-6. doi: 10.1159/000136881.
3
Tolerance to hexobarbital and supersensitivity to pilocarpine after chronic barbital treatments in the rat.大鼠长期接受巴比妥治疗后对己巴比妥的耐受性及对毛果芸香碱的超敏感性。
Eur J Pharmacol. 1976 Jul;38(1):123-9. doi: 10.1016/0014-2999(76)90208-9.
4
The interaction between atropine and the steric isomers of hexobarbital in normal rats and rats made tolerant to barbital.阿托品与己巴比妥的空间异构体在正常大鼠及对巴比妥产生耐受性的大鼠体内的相互作用。
Eur J Pharmacol. 1979 Nov 16;59(3-4):219-25. doi: 10.1016/0014-2999(79)90284-x.
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Some aspects of the changes induced by chronic barbital treatments in the male rat.慢性巴比妥处理对雄性大鼠所诱导变化的某些方面。
Drug Alcohol Depend. 1979 May-Jul;4(3-4):221-33. doi: 10.1016/0376-8716(79)90002-4.
6
The effects of atropine on the tolerance and the convulsions seen after withdrawal from forced barbital drinking in the rat.阿托品对大鼠强制饮用巴比妥后耐受性及戒断时惊厥的影响。
Psychopharmacology (Berl). 1978 Oct 31;59(2):123-8. doi: 10.1007/BF00427745.
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Potencies of barbiturates in mice selectively bred for resistance or susceptibility to nitrous oxide anesthesia.对氧化亚氮麻醉具有抗性或易感性的选择性培育小鼠中巴比妥类药物的效价。
Anesth Analg. 1984 Jan;63(1):35-9.
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Interaction of hydralazine with barbiturates.肼屈嗪与巴比妥类药物的相互作用。
Pol J Pharmacol Pharm. 1977 Jul-Aug;29(4):347-57.
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Potentiation of barbital hypnosis as an evaluation method for central nervous system depressants.将巴比妥催眠增强作为中枢神经系统抑制剂的一种评估方法。
Psychopharmacologia. 1965 Apr 7;7(5):374-8. doi: 10.1007/BF00403761.
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Studies on acute tolerance to ethanol in the abstinence period after long-term barbital treatment in the rat.大鼠长期巴比妥治疗后戒酒期乙醇急性耐受性的研究。
Acta Pharmacol Toxicol (Copenh). 1979 Aug;45(2):152-60. doi: 10.1111/j.1600-0773.1979.tb02375.x.

引用本文的文献

1
Barbitone-induced tolerance to the effects of sedative-hypnotics and related compounds on operant behaviour in the rat.巴比妥类药物诱导大鼠对镇静催眠药及相关化合物对其操作性行为影响的耐受性。
Br J Pharmacol. 1979 Feb;65(2):183-92. doi: 10.1111/j.1476-5381.1979.tb07817.x.
2
Potentiation of hexobarbital and amphetamine effects in male and female rats physically dependent on morphine.对吗啡产生身体依赖的雄性和雌性大鼠中，己巴比妥和苯丙胺作用的增强。
Psychopharmacology (Berl). 1978 Apr 28;57(2):175-83. doi: 10.1007/BF00426884.
3
Experimental dependence on barbiturates. II. Relationship between drug levels in serum and brain and the development of dependence in rats.

本文引用的文献

1
Induction of increased meprobamate metabolism in rats pretreated with some neurotropic drugs.用某些亲神经药物预处理的大鼠中眠尔通代谢增加的诱导作用。
Biochem Pharmacol. 1962 Aug;11:779-94. doi: 10.1016/0006-2952(62)90046-1.
2
DISTRIBUTION AND METABOLISM OF BARBITAL-14C IN TOLERANT AND NONTOLERANT RATS.巴比妥-14C在耐受和非耐受大鼠体内的分布与代谢
Biochem Pharmacol. 1964 Sep;13:1267-74. doi: 10.1016/0006-2952(64)90227-8.
3
The enzymatic metabolism of hexobarbital (evipal).己巴比妥（佛罗那）的酶促代谢
巴比妥类药物的实验性依赖。II. 大鼠血清和脑内药物水平与依赖性形成之间的关系。
Psychopharmacology (Berl). 1979 Jan 31;60(2):111-6. doi: 10.1007/BF00432280.
J Pharmacol Exp Ther. 1955 Aug;114(4):409-17.
4
The fate of pentobarbital in man and dog and a method for its estimation in biological material.戊巴比妥在人和狗体内的代谢情况及其在生物材料中的测定方法。
J Pharmacol Exp Ther. 1953 Sep;109(1):26-34.
5
Estimation of sensitivity to hexobarbitone (enhexymal NFN) in rats by an EEG threshold.通过脑电图阈值评估大鼠对己巴比妥（速可眠NFN）的敏感性。
Acta Pharmacol Toxicol (Copenh). 1966;24(4):404-18. doi: 10.1111/j.1600-0773.1966.tb00402.x.
6
Kinetics of pharmacologic effects.药理效应动力学
Clin Pharmacol Ther. 1966 May-Jun;7(3):362-72. doi: 10.1002/cpt196673362.
7
Hepatic drug-metabolising enzyme activity and duration of hexobarbitone anaesthesia in barbitone-dependent and withdrawn rats.巴比妥类药物依赖和戒断大鼠肝脏药物代谢酶活性及己巴比妥麻醉持续时间
Biochem Pharmacol. 1968 Nov;17(11):2297-305. doi: 10.1016/0006-2952(68)90037-3.
8
Differences in tolerance to hexobarbital (enhexymalum NFN) after barbital (diemalum NFN) pre-treatment during activity or rest.在活动期或休息期给予巴比妥（二乙基巴比妥钠NFN）预处理后，对己巴比妥（速可眠NFN）耐受性的差异。
Acta Pharmacol Toxicol (Copenh). 1968;26(1):92-104. doi: 10.1111/j.1600-0773.1967.tb00430.x.
9
Hexobarbital (enhexymalum NFN) sleeping times and EEG threshold doses as measurements of tolerance to barbiturates in the rat.己巴比妥（苯己比妥NFN）睡眠时间和脑电图阈剂量作为大鼠对巴比妥类药物耐受性的测量指标。
Acta Pharmacol Toxicol (Copenh). 1968;26(1):64-80. doi: 10.1111/j.1600-0773.1967.tb00428.x.
10
Changes in a hexobarbital anaesthesia threshold in rats induced by repeated long-term treatment with barbital or ethanol.巴比妥或乙醇长期反复治疗诱导的大鼠己巴比妥麻醉阈值变化
Psychopharmacologia. 1971;19(4):366-80. doi: 10.1007/BF00404381.