Polig E
Radiat Environ Biophys. 1976 Mar 30;13(1):27-41. doi: 10.1007/BF01323621.
Microradiographically detectable alterations of the bone structure in the femur of young rats induced by monomeric 241-Am(III) (i.v., 30 muCi/kg) were studied. The morphometric and dosimetric measurements were carried out by means of an electronic image analyzer. 8 weeks after injection of 241-Am a characteristic alteration of the frequency distribution of the chord lengths over the trabeculae in the epiphysis and over the metaphyseal marrow spaces was found. The structure of the spongiosa is irregular with both large, coarse and small fragmented trabeculae. The complexity of the bone architecture and the area of the endosteal surfaces is reduced. The surface/volume ratio in control animals varies between 36 mm-1 in the epiphysis and 64 mm-1 in the region of the epiphyseal cartilage plate. From the specific surface burden (pCi/mm2) the average dose rates were determined. There is no significant difference between the calcified tissue fraction in controls and animals with 241-Am, with the exception of the metaphyseal band where the locally high dose rates cause a devitalization of the tissue with inhibition of bone resorption as well as an abnormal trabeculation in the metaphysis. Treatment by Ca-DTPA reduces the 241-Am deposition nonuniformly and the pathological manifestations are markedly less pronounced. The mean trabecular width is about 100 mum in the epiphysis and has a minimum of 40 mum in the central part of the epiphyseal plate. The mean chord length over the marrow spaces varies between 90 and 210 mum.
研究了静脉注射单体241-镅（III）（30微居里/千克）诱导的幼鼠股骨骨结构的显微放射学可检测变化。通过电子图像分析仪进行形态测量和剂量测量。注射241-镅8周后，发现骨骺小梁和弦长以及干骺端骨髓腔频率分布的特征性变化。松质骨结构不规则，既有大的、粗大的小梁，也有小的破碎小梁。骨结构的复杂性和骨内膜表面面积减小。对照动物的表面/体积比在骨骺处为36毫米-1，在骨骺软骨板区域为64毫米-1。根据比表面负荷（皮居里/平方毫米）确定平均剂量率。对照动物和接受241-镅的动物的钙化组织分数之间没有显著差异，但干骺端带除外，在该区域局部高剂量率导致组织失活，抑制骨吸收，并在干骺端出现异常小梁形成。用Ca-DTPA治疗可使241-镅的沉积不均匀减少，病理表现明显减轻。骨骺处小梁平均宽度约为100微米，在骨骺板中央部分最小为40微米。骨髓腔上的平均弦长在90至210微米之间。
