内皮素拮抗剂对心肌梗死犬的血流动力学影响。

Hemodynamic effect of endothelin antagonists in dogs with myocardial infarction.

作者信息

Ohta H, Suzuki J, Akima T, Kawai N, Hanada K, Nishikibe M

机构信息

Department of Pharmacology, Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., Japan.

出版信息

J Cardiovasc Pharmacol. 1998;31 Suppl 1:S255-7. doi: 10.1097/00005344-199800001-00072.

DOI:10.1097/00005344-199800001-00072

PMID:9595453

Abstract

The hemodynamic effects of enalapril, an angiotensin-converting enzyme inhibitor, BQ-123, a selective ETA receptor antagonist, and bosentan, a nonselective ETA and ETB receptor antagonist, were studied in dogs 4 weeks after myocardial infarction (MI) produced by ligation of the left anterior descending coronary artery. Reduced arterial pressure and total peripheral resistance after administration of analapril, BQ-123, and bosentan revealed that both the renin-angiotensin system and endothelin participate in maintenance of cardiovascular function in chronic MI.

摘要

在通过结扎左冠状动脉前降支产生心肌梗死（MI）4周后的犬中，研究了血管紧张素转换酶抑制剂依那普利、选择性ETA受体拮抗剂BQ - 123和非选择性ETA及ETB受体拮抗剂波生坦的血流动力学效应。给予依那普利、BQ - 123和波生坦后动脉压和总外周阻力降低，这表明肾素 - 血管紧张素系统和内皮素均参与慢性心肌梗死中心血管功能的维持。