de Blay F, Purohit A, Stenger R, Gries P, Hamberger C, David B, Frossard N, Pauli G
Unité INSERM U425, Pavillon Laennec, Hôpitaux Universitaires de Strasbourg, France.
Eur Respir J. 1998 Mar;11(3):594-8.
We performed a prospective study in order: 1) to determine whether a correlation could be found between serum eosinophil cationic protein (ECP) levels and clinical and functional status in perennial asthmatics during a 5 month prospective study; and 2) to evaluate the relationship between allergic exposure and ECP levels in periodic asthmatics. Two groups of asthmatic patients were selected: a group of acutely ill perennial asthmatics and a group of periodic asthmatics. The acutely ill perennial asthmatics (n=22, mean age=39.4 yrs) were included on the basis of hospitalization for acute asthma. At the end of the hospitalization, there was a 5 month follow-up of clinical, functional and medication scores, as well as eosinophil counts and ECP levels. The periodic asthmatic group was composed of asthmatics sensitized to birch and tree pollens (n=10, mean age=33.8 yrs). The same measurement were performed on this group, before, during and after the pollen season. Under corticosteroid treatment in the acutely ill patients, there was a significant decrease in serum ECP levels between the first day of hospitalization and the day of discharge (mean: 23.2 microg x L(-1) and 9.5 microg x L(-1), respectively; p=0.006). No correlation was found between the clinical status, functional status and serum ECP levels during the 5 month follow-up. A significant increase in ECP levels was found in periodic asthmatics during the pollen season. Our results suggest that serum eosinophil cationic protein is a useful marker of allergen exposure and of acute asthma treatment. This could be of importance in the prevention and follow-up of allergic asthma; the value of serum eosinophil cationic protein measurements in the day-to-day management of adult asthmatics needs to be further clarified.
我们进行了一项前瞻性研究，目的如下：1）在一项为期5个月的前瞻性研究中，确定常年性哮喘患者血清嗜酸性粒细胞阳离子蛋白（ECP）水平与临床及功能状态之间是否存在相关性；2）评估间歇性哮喘患者中变应原暴露与ECP水平之间的关系。选取了两组哮喘患者：一组是急性发作的常年性哮喘患者，另一组是间歇性哮喘患者。急性发作的常年性哮喘患者（n = 22，平均年龄 = 39.4岁）因急性哮喘住院而入选。住院结束时，对临床、功能和用药评分以及嗜酸性粒细胞计数和ECP水平进行了为期5个月的随访。间歇性哮喘组由对桦树和树木花粉致敏的哮喘患者组成（n = 10，平均年龄 = 33.8岁）。在花粉季节之前、期间和之后，对该组进行了同样的测量。在急性病患者接受皮质类固醇治疗的情况下，住院第一天至出院当天血清ECP水平显著下降（平均值分别为23.2μg×L⁻¹和9.5μg×L⁻¹；p = 0.006）。在5个月的随访期间，未发现临床状态、功能状态与血清ECP水平之间存在相关性。在花粉季节，间歇性哮喘患者的ECP水平显著升高。我们的结果表明，血清嗜酸性粒细胞阳离子蛋白是变应原暴露和急性哮喘治疗的有用标志物。这在过敏性哮喘的预防和随访中可能具有重要意义；血清嗜酸性粒细胞阳离子蛋白测量在成年哮喘患者日常管理中的价值需要进一步阐明。
