β受体阻滞剂治疗自主神经反射异常：一例病例报告及文献复习

Beta blockade in the treatment of autonomic dysreflexia: a case report and review.

作者信息

Pasquina P F, Houston R M, Belandres P V

机构信息

Physical Medicine and Rehabilitation, Walter Reed Army Medical Center, Washington, DC 20307-5001, USA.

出版信息

Arch Phys Med Rehabil. 1998 May;79(5):582-4. doi: 10.1016/s0003-9993(98)90077-6.

DOI:10.1016/s0003-9993(98)90077-6

PMID:9596403

Abstract

Autonomic dysreflexia has long been considered a sympathetically mediated phenomenon. Recent articles have reported the use of alpha blockers as a means of treatment. We report the case of a 20-year-old C5 American Spinal Injury Association A spinal cord injured patient who almost daily experienced symptoms of headache, facial flushing, and hypertension consistent with autonomic dysreflexia. These symptoms caused him frequent discomfort and anxiety. Despite an extensive workup, we were unable to identify a source of his dysreflexic episodes. After starting metoprolol 50 mg every night, however, these episodes stopped and the patient showed no adverse effects from the medication.

摘要

自主神经反射异常长期以来一直被认为是一种由交感神经介导的现象。近期的文章报道了使用α受体阻滞剂作为一种治疗手段。我们报告了一例20岁的美国脊髓损伤协会（ASIA）A级C5脊髓损伤患者，该患者几乎每天都出现与自主神经反射异常相符的头痛、面部潮红和高血压症状。这些症状给他带来了频繁的不适和焦虑。尽管进行了广泛的检查，但我们未能确定其反射异常发作的根源。然而，在每晚开始服用50毫克美托洛尔后，这些发作停止了，且患者未出现该药物的不良反应。