Hogg J C, Stein L, Martin R, Macklem P T
Respir Physiol. 1976 Aug;27(2):207-21. doi: 10.1016/0034-5687(76)90075-x.
The deformation of the lung by the chest wall was observed on radiographs of the ribs and interspaces and on morphologic preparations of samples cut from the frozen thorax. The effect of these deformities on the distribution of ventilation and regional lung volume of the underlying lung was determined using Xenon 133. We found that ribs and interspaces deform the lung surface with different radii of curvature, suggesting local differences in pleural pressure and that traction on the thoracic limb caused deformities in the underlying interspaces which were similar to those produced by 20 cm H2O mouth pressure. Xenon 133 showed that these changes in pressure had no effect on the regional volume or on ventilation distribution in the underlying lung. We conclude that changes in pleural pressure produced by localized deformities exert their effect close to the deformity and that the underlying lung responds to the average pressure exerted over a much larger area of the pleural surface.
通过肋骨和肋间隙的X光片以及从冰冻胸廓切取的样本的形态学标本，观察到胸壁对肺的变形情况。使用氙133测定了这些畸形对其下方肺的通气分布和区域肺容积的影响。我们发现，肋骨和肋间隙以不同的曲率半径使肺表面变形，提示胸膜压力存在局部差异，并且胸肢的牵拉导致其下方肋间隙出现畸形，这些畸形与20厘米水柱口腔压力所产生的畸形相似。氙133显示，这些压力变化对其下方肺的区域容积或通气分布没有影响。我们得出结论，局部畸形产生的胸膜压力变化在靠近畸形处发挥作用，而下方的肺对胸膜表面更大区域所施加的平均压力作出反应。
