[BOOP与UIP之间BALF细胞学的鉴别]
[Differentiation of cytology of BALF between BOOP and UIP].
作者信息
Zhong D, Shi H
机构信息
Department of Respiratory Disease, First Affiliated Hospital, Guangxi Medical University, Nanning.
出版信息
Zhonghua Jie He He Hu Xi Za Zhi. 1996 Oct;19(5):276-8.
OBJECTIVE
BOOP is a disease entity proposed by Epler in 1985, and UIP is considered an important disease to be differentiated from BOOP. The aim of this study was to identify characteristic features in BALF samples of patients with BOOP and UIP.
METHODS
Differential cell count and T-cell subpopulation of the BALF obtained from 7 patients with BOOP and 7 patients with UIP, both histologically verified, were determined.
RESULTS
In BOOP patients the ratio of lymphocytes and the CD8+ cell in BALF were significantly higher and CD4+/cd8+ ratio was significantly lower than those of the UIP patients (P < 0.01). In UIP patients the ratio of neutrophils in BALF was significantly higher than that of the BOOP patients (P < 0.05).
CONCLUSIONS
Cytological examination of BALF is effective in differentiating BOOP from UIP and it can provide useful information about both different pathogenetic processes of the two entities.
目的
闭塞性细支气管炎伴机化性肺炎（BOOP）是1985年由埃普勒提出的一种疾病实体，而寻常型间质性肺炎（UIP）被认为是一种需要与BOOP相鉴别的重要疾病。本研究的目的是确定BOOP和UIP患者支气管肺泡灌洗（BALF）样本中的特征性表现。
方法
对7例经组织学证实的BOOP患者和7例UIP患者的BALF进行细胞分类计数和T细胞亚群测定。
结果
BOOP患者BALF中淋巴细胞和CD8⁺细胞比例显著高于UIP患者，CD4⁺/CD8⁺比例显著低于UIP患者（P<0.01）。UIP患者BALF中中性粒细胞比例显著高于BOOP患者（P<0.05）。
结论
BALF的细胞学检查对BOOP与UIP的鉴别有效，且能为这两种疾病不同的发病机制提供有用信息。
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