Chen X, Tang P, Li Y
Children's Hospital, Zhejiang Medical University, Hangzhon.
Zhonghua Jie He He Hu Xi Za Zhi. 1996 Oct;19(5):282-5.
To understand the relationship between IgE and asthma, and the genetic background of IgE.
The authors measured serum total IgE in 121 healty subjects and 100 asthmatic children (CAC-IRMA) and investigated three AA families with total IgE evaluation and genetic linkage analysis between IgE and D11S533.
The IgE cutoff point between low and high was defined at 150 kU/L. There were 33.1% population with high level of total IgE. Of the 100 asthmatic children 96% had higher IgE level than controls, the difference was significant (P < 0.001). The IgE level of 22 asthmatic children in their releases had no significant difference compared with that in their attacks. In 40 members of three atopic asthma families, there were 23 persons with high IgE and 15 with asthma. In these families high IgE level were found both in male and female and the affected person occured in consecutive three generations, which fit to AD inheritance. Family 1 and 3 generally showed a high level of IgE, while family 2 showed low level of IgE. Two point linkage analysis between IgE and D11S533 showed that there were two recombinants from 22 meioses in the two families with a maximum lod score 1.074 at a recombination fraction of 0.05.
Most of asthma children have high IgE, which seems obtained from birth. About 1/3 population have high level IgE who are potential atopic persons. IgE level in human beings in inherited by AD mode. IgE gene may be close to 11q13.3-13.4.
了解IgE与哮喘的关系以及IgE的遗传背景。
作者采用CAC-IRMA法检测了121名健康受试者和100名哮喘儿童的血清总IgE，并对3个过敏性哮喘家系进行了总IgE评估以及IgE与D11S533之间的遗传连锁分析。
将总IgE高低分界点定义为150 kU/L。总IgE水平高的人群占33.1%。100名哮喘儿童中，96%的患儿IgE水平高于对照组，差异有统计学意义（P < 0.001）。22名哮喘儿童缓解期的IgE水平与发作期相比差异无统计学意义。在3个过敏性哮喘家系的40名成员中，23人IgE水平高，15人患哮喘。这些家系中，男女均有IgE水平高的情况，且患者连续出现三代，符合常染色体显性遗传。家系1和3总体上显示IgE水平高，而家系2显示IgE水平低。IgE与D11S533之间的两点连锁分析显示，两个家系的22次减数分裂中有2个重组体，在重组率为0.05时最大对数计分1.074。
大多数哮喘儿童IgE水平高，似乎从出生就有。约1/3人群IgE水平高，为潜在的特应性个体。人类IgE水平呈常染色体显性遗传方式。IgE基因可能位于11q13.3 - 13.4附近。
