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[侧脑室引流及药物注射治疗结核性脑膜炎继发性脑积水]

[Treatment of the secondary hydrocephalus of tuberculous meningitis by lateral ventricular drainage and drug injection].

作者信息

Chen Y, Chang F, Wang Z

机构信息

262th Hospital of P.L.A, Beijing.

出版信息

Zhonghua Jie He He Hu Xi Za Zhi. 1996 Oct;19(5):297-9.

PMID:9596845
Abstract

OBJECTIVE

To decrease intracranial pressure rapidly and cure the secondary hydrocephalus of tuberculous meningitis.

METHODS

Every case was drained at the frontal horn of lateral ventricle of non-predominant cerebral hemisphere, injected the mixture of 100 mg isoniazid and 2 mg dexamethasone into the lateral ventricle through ventricular drainage tube once every two days or once every day in some severe cases.

RESULTS

The high intracranial pressure of 23 cases suffered from tuberculous meningitis were immediately decreased to normal level. The symptoms of 8 cases complicated with brain hernia were quickly improved. The cerebrospinal fluid became normal within 2-4 weeks after lateral ventricular drug injection.

CONCLUSIONS

Lateral ventricular drainage and drug injection can obtain good result and provide a new approach to treatment of secondary hydrocephalus cases suffered from tuberculous meningitis.

摘要

目的

迅速降低颅内压,治疗结核性脑膜炎继发性脑积水。

方法

每例均于非优势大脑半球侧脑室额角进行引流,通过脑室引流管每两天向侧脑室内注入100mg异烟肼与2mg地塞米松的混合液,部分重症病例每天注入一次。

结果

23例结核性脑膜炎患者的高颅内压立即降至正常水平。8例合并脑疝的患者症状迅速改善。侧脑室注药后2 - 4周脑脊液恢复正常。

结论

侧脑室引流及注药可取得良好效果,为结核性脑膜炎继发性脑积水病例的治疗提供了新途径。

相似文献

1
[Treatment of the secondary hydrocephalus of tuberculous meningitis by lateral ventricular drainage and drug injection].[侧脑室引流及药物注射治疗结核性脑膜炎继发性脑积水]
Zhonghua Jie He He Hu Xi Za Zhi. 1996 Oct;19(5):297-9.
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[Case of tuberculous meningitis with hydrocephalus and hypothermia].
Nihon Naika Gakkai Zasshi. 1996 Jan 10;85(1):113-4.
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[A case of refractory tuberculous meningitis markedly improved by intrathecal administration of isoniazid (INH)].[1例经鞘内注射异烟肼(INH)后显著改善的难治性结核性脑膜炎病例]
Rinsho Shinkeigaku. 2003 Jan-Feb;43(1-2):20-5.
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[Evaluation of the treatment of adult tuberculous meningitis].[成人结核性脑膜炎治疗的评估]
Zhonghua Jie He He Hu Xi Za Zhi. 1992 Apr;15(2):79-80, 126.
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[An adult case of tuberculous meningitis].[一例成人结核性脑膜炎病例]
Nihon Kokyuki Gakkai Zasshi. 2003 Apr;41(4):294-9.
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[Tuberculous meningitis developed during treatment for systemic lupus erythematosus (SLE)].在系统性红斑狼疮(SLE)治疗期间发生了结核性脑膜炎。
Kekkaku. 1999 Jan;74(1):27-32.
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[Ventriculoperitoneal shunt for hydrocephalus secondary to tuberculous meningitis: a case report].[脑室腹腔分流术治疗结核性脑膜炎继发脑积水:一例报告]
No Shinkei Geka. 1989 Jun;17(6):589-92.
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Hydrocephalus in tuberculous meningitis: Incidence, its predictive factors and impact on the prognosis.结核性脑膜炎并发脑积水:发生率、预测因素及其对预后的影响。
J Infect. 2013 Apr;66(4):330-7. doi: 10.1016/j.jinf.2012.12.009. Epub 2013 Jan 2.
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[Treatment of intractable tuberculous meningitis using intrathecal isoniazid administration and steroid pulse therapy; a report of two cases].[鞘内注射异烟肼联合类固醇脉冲疗法治疗难治性结核性脑膜炎;两例报告]
Rinsho Shinkeigaku. 2012;52(8):551-6. doi: 10.5692/clinicalneurol.52.551.
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[Lateroventriculostomy in treating 360 cases of tuberculous meningitis complicated by hydrocephalus].侧脑室造瘘术治疗360例结核性脑膜炎合并脑积水
Zhonghua Yi Xue Za Zhi. 1987 Sep;67(9):506-7.

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Comprehensive Therapeutic Approaches to Tuberculous Meningitis: Pharmacokinetics, Combined Dosing, and Advanced Intrathecal Therapies.结核性脑膜炎的综合治疗方法:药代动力学、联合给药及鞘内高级治疗
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Role of ventriculoperitoneal shunt surgery in grade IV tubercular meningitis with hydrocephalus.
脑室腹腔分流术在IV级结核性脑膜炎合并脑积水治疗中的作用。
Childs Nerv Syst. 2012 Feb;28(2):209-15. doi: 10.1007/s00381-011-1572-0. Epub 2011 Sep 11.