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空肠弯曲菌肠炎后伴传导阻滞的急性多灶性运动神经病1例

[A case of acute multifocal motor neuropathy with conduction block after Campylobacter jejuni enteritis].

作者信息

Sugie K, Murata K, Ikoma K, Suzumura A, Takayanagi T

机构信息

Department of Neurology, Nara Medical University.

出版信息

Rinsho Shinkeigaku. 1998 Jan;38(1):42-5.

PMID:9597909
Abstract

The patient was a 25-year-old male with acute multifocal motor neuropathy with conduction block (MMNCB) after Campylobacter jejuni enteritis. After having suffered from diarrhea for 3 days, he rapidly developed asymmetrical distal-dominant muscle weakness in all extremities. Sensory disturbance was unremarkable except for slight disturbance in deep sensation. Deep tendon reflexes were normal throughout the course of present illness. CSF analysis revealed increased protein up to 66 mg/dl without pleocytosis. In electrophysiological examinations, persistant multifocal conduction blocks in the motor nerves were predominantly noted in the distal part of the extremities. Serum titers of anti-Campylobacter jejuni antibody, anti-GM1 antibody and anti-GalNAc-GD1a antibody were elevated. Muscle weakness resolved completely within 7 weeks. The sural nerve biopsy did not reveal either axonal degeneration, nor demyelination. These clinical and laboratory findings suggested that this case was most likely an acute type of MMNCB after Campylobacter jejuni enteritis.

摘要

该患者为一名25岁男性,空肠弯曲菌肠炎后发生急性多灶性运动神经病伴传导阻滞(MMNCB)。腹泻3天后,他迅速出现四肢不对称的以远端为主的肌无力。除了深感觉有轻微障碍外,感觉障碍不明显。在目前疾病的整个过程中,深腱反射均正常。脑脊液分析显示蛋白升高至66mg/dl,无细胞增多。在电生理检查中,运动神经持续存在的多灶性传导阻滞主要见于四肢远端。抗空肠弯曲菌抗体、抗GM1抗体和抗GalNAc-GD1a抗体的血清滴度升高。肌无力在7周内完全缓解。腓肠神经活检未发现轴突变性或脱髓鞘。这些临床和实验室检查结果表明,该病例很可能是空肠弯曲菌肠炎后急性型MMNCB。

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