• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Role of deoxycytidine kinase (dCK), thymidine kinase 2 (TK2), and deoxycytidine deaminase (dCDA) in the antitumor activity of gemcitabine (dFdC).

作者信息

Kroep J R, van Moorsel C J, Veerman G, Voorn D A, Schultz R M, Worzalla J F, Tanzer L R, Merriman R L, Pinedo H M, Peters G J

机构信息

Department of Med. Oncology, University Hospital VU, Amsterdam, The Netherlands.

出版信息

Adv Exp Med Biol. 1998;431:657-60. doi: 10.1007/978-1-4615-5381-6_127.

DOI:10.1007/978-1-4615-5381-6_127
PMID:9598147
Abstract
摘要

相似文献

1
Role of deoxycytidine kinase (dCK), thymidine kinase 2 (TK2), and deoxycytidine deaminase (dCDA) in the antitumor activity of gemcitabine (dFdC).脱氧胞苷激酶（dCK）、胸苷激酶2（TK2）和脱氧胞苷脱氨酶（dCDA）在吉西他滨（dFdC）抗肿瘤活性中的作用。
Adv Exp Med Biol. 1998;431:657-60. doi: 10.1007/978-1-4615-5381-6_127.
2
Collateral sensitivity to gemcitabine (2',2'-difluorodeoxycytidine) and cytosine arabinoside of daunorubicin- and VM-26-resistant variants of human small cell lung cancer cell lines.人小细胞肺癌细胞系中柔红霉素和VM - 26耐药变体对吉西他滨（2'，2'-二氟脱氧胞苷）和阿糖胞苷的 collateral敏感性 。 （注：这里“collateral sensitivity”直接翻译是“ collateral敏感性” ，可能在医学中有特定含义，需结合上下文理解，也许是“协同敏感性”之类更准确的表述 ）
Biochem Pharmacol. 2001 Jun 1;61(11):1401-8. doi: 10.1016/s0006-2952(01)00627-x.
3
Decreased resistance to gemcitabine (2',2'-difluorodeoxycitidine) of cytosine arabinoside-resistant myeloblastic murine and rat leukemia cell lines: role of altered activity and substrate specificity of deoxycytidine kinase.阿糖胞苷耐药的小鼠和大鼠髓母细胞白血病细胞系对吉西他滨（2'，2'-二氟脱氧胞苷）的耐药性降低：脱氧胞苷激酶活性和底物特异性改变的作用
Biochem Pharmacol. 1999 Feb 15;57(4):397-406. doi: 10.1016/s0006-2952(98)00318-9.
4
Induction of in vivo resistance against gemcitabine (dFdC, 2',2'-difluoro-deoxycytidine).体内诱导对吉西他滨（2',2'-二氟脱氧胞苷，dFdC）的抗性。
Adv Exp Med Biol. 1998;431:637-40. doi: 10.1007/978-1-4615-5381-6_123.
5
siRNA knockdown of mitochondrial thymidine kinase 2 (TK2) sensitizes human tumor cells to gemcitabine.线粒体胸苷激酶2（TK2）的小干扰RNA敲低使人类肿瘤细胞对吉西他滨敏感。
Oncotarget. 2015 Sep 8;6(26):22397-409. doi: 10.18632/oncotarget.4272.
6
Induction of resistance to 2',2'-difluorodeoxycytidine in the human ovarian cancer cell line A2780.人卵巢癌细胞系A2780对2',2'-二氟脱氧胞苷耐药性的诱导
Semin Oncol. 1995 Aug;22(4 Suppl 11):35-41.
7
Deoxycytidine kinase and deoxycytidine deaminase activities in human tumour xenografts.人肿瘤异种移植中的脱氧胞苷激酶和脱氧胞苷脱氨酶活性
Eur J Cancer. 1993;29A(15):2132-7. doi: 10.1016/0959-8049(93)90048-k.
8
Determinants of sensitivity and resistance to gemcitabine: the roles of human equilibrative nucleoside transporter 1 and deoxycytidine kinase in non-small cell lung cancer.吉西他滨敏感性和耐药性的决定因素：人平衡核苷转运体1和脱氧胞苷激酶在非小细胞肺癌中的作用
Cancer Sci. 2004 Sep;95(9):753-7. doi: 10.1111/j.1349-7006.2004.tb03257.x.
9
Quantitative Targeted Proteomics of Pancreatic Cancer: Deoxycytidine Kinase Protein Level Correlates to Progression-Free Survival of Patients Receiving Gemcitabine Treatment.胰腺癌的定量靶向蛋白质组学：脱氧胞苷激酶蛋白水平与接受吉西他滨治疗患者的无进展生存期相关。
Mol Pharm. 2015 Sep 8;12(9):3282-91. doi: 10.1021/acs.molpharmaceut.5b00282. Epub 2015 Aug 25.
10
Cytotoxic activity of 2',2'-difluorodeoxycytidine, 5-aza-2'-deoxycytidine and cytosine arabinoside in cells transduced with deoxycytidine kinase gene.脱氧胞苷激酶基因转导细胞中2',2'-二氟脱氧胞苷、5-氮杂-2'-脱氧胞苷和阿糖胞苷的细胞毒性活性
Biochem Biophys Res Commun. 2002 May 24;293(5):1478-84. doi: 10.1016/S0006-291X(02)00413-8.

引用本文的文献

1
Exploring a Gemcitabine-Glucose Hybrid as a Glycoconjugate Prodrug.探索吉西他滨-葡萄糖杂合物作为糖缀合物前药。
ACS Omega. 2024 Jul 9;9(29):31703-31713. doi: 10.1021/acsomega.4c02417. eCollection 2024 Jul 23.
2
Synthesis and anticancer evaluation of acetylated-lysine conjugated gemcitabine prodrugs.乙酰化赖氨酸共轭吉西他滨前药的合成与抗癌评估
RSC Med Chem. 2023 Jul 6;14(8):1572-1580. doi: 10.1039/d3md00190c. eCollection 2023 Aug 16.
3
Gemcitabine Peptide-Based Conjugates and Their Application in Targeted Tumor Therapy.基于吉西他滨的肽类偶联物及其在靶向肿瘤治疗中的应用。
Molecules. 2021 Jan 12;26(2):364. doi: 10.3390/molecules26020364.
4
Combination of Gemcitabine with Cell-Penetrating Peptides: A Pharmacokinetic Approach Using In Silico Tools.吉西他滨与穿膜肽的联合应用：一种基于计算工具的药代动力学方法。
Biomolecules. 2019 Nov 4;9(11):693. doi: 10.3390/biom9110693.
5
Synthesis and cytostatic evaluation of 4-N-alkanoyl and 4-N-alkyl gemcitabine analogues.合成及 4-N-烷酰基和 4-N-烷基吉西他滨类似物的细胞抑制活性评价。
J Med Chem. 2014 Jan 9;57(1):191-203. doi: 10.1021/jm401586a. Epub 2013 Dec 30.
6
Preclinical absorption, distribution, metabolism, and excretion of an oral amide prodrug of gemcitabine designed to deliver prolonged systemic exposure.一种口服酰胺前药的临床前吸收、分布、代谢和排泄研究，旨在提供延长的全身暴露。
Pharmaceutics. 2013 May 8;5(2):261-76. doi: 10.3390/pharmaceutics5020261.
7
Automated mass action model space generation and analysis methods for two-reactant combinatorially complex equilibriums: an analysis of ATP-induced ribonucleotide reductase R1 hexamerization data.两反应物组合复杂平衡的自动批量作用模型空间生成和分析方法：对 ATP 诱导的核糖核苷酸还原酶 R1 六聚体化数据的分析。
Biol Direct. 2009 Dec 9;4:50. doi: 10.1186/1745-6150-4-50.
8
Quantification of chemotherapeutic target gene mRNA expression in human breast cancer biopsies: comparison of real-time reverse transcription-PCR vs. relative quantification reverse transcription-PCR utilizing DNA sequencer analysis of PCR products.人乳腺癌活检组织中化疗靶基因mRNA表达的定量分析：实时逆转录PCR与利用PCR产物DNA测序仪分析的相对定量逆转录PCR的比较
J Clin Lab Anal. 2003;17(5):184-94. doi: 10.1002/jcla.10091.
9
Clinical pharmacokinetics of nucleoside analogues: focus on haematological malignancies.核苷类似物的临床药代动力学：聚焦血液系统恶性肿瘤
Clin Pharmacokinet. 2000 Jul;39(1):5-26. doi: 10.2165/00003088-200039010-00002.