Mathers D H, Holsinger J W, Miscia V F
South Med J. 1976 Aug;69(8):1079-84. doi: 10.1097/00007611-197608000-00041.
Of the commonly used drugs, digitalis has one of the highest therapeutic-toxic ratios. Mortality is significantly increased in the 20% to 30% of patients on digitalis who are in a toxic state when admitted to the hospital. Successful use of digitalis depends on avoidance of its use in situations likely to result in toxicity; recognition of the signs, symptoms, and electrocardiographic findings of digitalis intoxication; and stopping digitalis completely as the initial treatment of digitalis intoxication.
在常用药物中,洋地黄的治疗-毒性比是最高的之一。在入院时处于中毒状态的服用洋地黄的患者中,有20%至30%的患者死亡率显著增加。洋地黄的成功使用取决于避免在可能导致毒性的情况下使用;识别洋地黄中毒的体征、症状和心电图表现;以及在洋地黄中毒的初始治疗中完全停用洋地黄。