肿瘤坏死因子对病毒诱导的细胞凋亡的加速作用。
Acceleration of virus-induced apoptosis by tumor necrosis factor.
作者信息
Koyama A H, Arakawa T, Adachi A
机构信息
Department of Virology, School of Medicine, The University of Tokushima, Japan.
出版信息
FEBS Lett. 1998 Apr 17;426(2):179-82. doi: 10.1016/s0014-5793(98)00338-x.
The multiplication of vesicular stomatitis virus in HeLa cells was inhibited by treating the cells with tumor necrosis factor (TNF). Comparison of the kinetics of virus multiplication and that of virus-induced apoptosis in the TNF-treated cells revealed that the antiviral effect of TNF is accompanied by a rapid induction of apoptosis in the cells upon infection, suggesting that TNF can inhibit virus multiplication by accelerating an apoptotic response in the infected cells.
用肿瘤坏死因子（TNF）处理HeLa细胞后，水泡性口炎病毒在这些细胞中的增殖受到抑制。对经TNF处理的细胞中病毒增殖动力学与病毒诱导的细胞凋亡动力学进行比较后发现，TNF的抗病毒作用伴随着感染后细胞凋亡的快速诱导，这表明TNF可通过加速受感染细胞中的凋亡反应来抑制病毒增殖。
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