Hansen D S, Sirot D, Kolmos H J
Statens Serum Institut, København.
Ugeskr Laeger. 1998 Apr 6;160(15):2261-2.
This study presents the first two cases of infections with Klebsiella pneumoniae producing extended spectrum betalactamases (ESBL) that have been recorded in Denmark. They presented as a urinary tract infection and a generalized infection in a patient admitted to an intensive care unit. Both patients had been treated with broad spectrum antibiotics prior to infection. Presumably, one of the strains had been imported from Turkey. The ESBL of the two strains were characterized as SHV-2 and SHV-5, respectively. Patients transferred from hospitals abroad should be screened for Klebsiella producing ESBL, in addition to MRSA and other multiresistant organisms. A restrictive antibiotic policy and strict hygienic precautions are essential measures to control the selection and spread of such organisms in the hospital environment.
本研究报告了丹麦首次记录的两例产超广谱β-内酰胺酶（ESBL）的肺炎克雷伯菌感染病例。这两例病例分别表现为一名入住重症监护病房患者的尿路感染和全身性感染。两名患者在感染前均接受过广谱抗生素治疗。据推测，其中一株菌株是从土耳其传入的。这两株菌株的ESBL分别被鉴定为SHV-2和SHV-5。除耐甲氧西林金黄色葡萄球菌（MRSA）和其他多重耐药菌外，从国外医院转诊来的患者还应筛查产ESBL的克雷伯菌。限制使用抗生素政策和严格的卫生预防措施是控制此类病菌在医院环境中产生和传播的重要措施。
