Frisch M, Hjalgrim H, Olsen J H, Melbye M
Afdeling for epidemiologisk forskning, Statens Serum Institut, København.
Ugeskr Laeger. 1998 May 4;160(19):2882-7.
A population-based cohort of 37,674 patients diagnosed during the period 1978-1991 and registered in the Danish Cancer Registry with basal cell carcinoma of the skin (BCC) were followed for the occurrence of new malignancies. BCC patients experienced significantly increased cancer incidence rates compared with the general Danish population. The elevated cancer risk was not restricted to new cutaneous malignancies. Cancers at various sites, including lip, salivary glands, larynx, lung, breast, kidney and non-Hodgkin lymphoma occurred in significant excess. Patients diagnosed with BCC before the age of 60 years were at higher risk of developing new malignancies than patients diagnosed with BCC at an older age. This age association pertained particularly to breast cancer, testicular cancer and non-Hodgkin lymphoma.
对1978年至1991年期间确诊并在丹麦癌症登记处登记患有皮肤基底细胞癌（BCC）的37674名患者进行了基于人群的队列研究，以观察新发恶性肿瘤的发生情况。与丹麦普通人群相比，BCC患者的癌症发病率显著增加。癌症风险升高并不局限于新发皮肤恶性肿瘤。包括唇部、唾液腺、喉、肺、乳腺、肾和非霍奇金淋巴瘤在内的各个部位的癌症均显著增多。60岁之前被诊断为BCC的患者比年龄较大时被诊断为BCC的患者发生新发恶性肿瘤的风险更高。这种年龄关联尤其适用于乳腺癌、睾丸癌和非霍奇金淋巴瘤。
