Gratacap-Cavallier B, Morand P, Dutertre N, Bosson J L, Baccard-Longère M, Jouk P S, Cans C, Jean D, Cart-Lamy P, Vandekerckhove C, Benbassa A, Micoud M, Seigneurin J M
Laboratoire de Virologie, CHU Michallon, Grenoble.
J Gynecol Obstet Biol Reprod (Paris). 1998 Mar;27(2):161-6.
Cytomegalovirus (CMV) is the leading cause of viral congenital infections. In children, the consequences may be severe, especially in case of maternal primary infection during pregnancy. A prospective study was carried out in the department of Isère, in 1,018 pregnant women, in order to establish the seroprevalence of CMV, the frequency of primary infections during pregnancy and the associated risk factors. The overall seroprevalence was 51.5%; it increased significantly with age, parity, and low socioeconomic status. It was higher in women born in the South of France (51.6%) than in those born in the North (37.4%). Among a total of 878 women with serological follow-up, 7 primary infection cases (0.8%) were observed. Seventeen women (1.9%) presented border IgM values in the first serum, and these values were not related to recent infection. Extrapolation of the results to the whole department of Isère, suggests that each year about 100 pregnant women would be concerned by CMV primary infection, with 2 or 3 cases of death or severe sequelae in children. In light of these results, the interest of serological screening is discussed.
巨细胞病毒（CMV）是先天性病毒感染的主要原因。对于儿童来说，后果可能很严重，尤其是在孕期母亲初次感染的情况下。伊泽尔省开展了一项针对1018名孕妇的前瞻性研究，以确定CMV的血清阳性率、孕期初次感染的频率及相关风险因素。总体血清阳性率为51.5%；其随年龄、产次和低社会经济地位显著上升。出生于法国南部的女性（51.6%）高于出生于北部的女性（37.4%）。在总共878名接受血清学随访的女性中，观察到7例初次感染病例（0.8%）。17名女性（1.9%）首次血清检测时IgM值处于临界水平，且这些值与近期感染无关。将结果推算至整个伊泽尔省，表明每年约有100名孕妇会受到CMV初次感染影响，其中有2至3例儿童死亡或严重后遗症病例。鉴于这些结果，对血清学筛查的意义进行了讨论。
