Krajcar J, Radaković B, Stefanić L
Porec Health Center, Croatia.
Acta Med Croatica. 1998;52(1):65-9.
Pregnancy is a risk factor for venous insufficiency. Up to 30 percent of women will develop venous insufficiency during their first pregnancy, and with each next pregnancy its prevalence is higher. Several pathophysiologic mechanisms are involved in the pathophysiology of venous insufficiency during pregnancy. The role of these mechanisms in the pathophysiology of venous insufficiency during pregnancy is still a point of discussion. Mechanical compression of enlarged uterus on pelvic veins was the first considered responsible for the occurrence of venous insufficiency during pregnancy. Soon, it was found that hormonal changes in pregnancy cause reduction in venous tone, and this reduction was postulated to be a major factor in pathophysiology of venous insufficiency. In a large number of subsequent studies both hypotheses were tested, being confirmed or rejected, but no consensus has been reached. This paper reviews current knowledge regarding pathophysiology of venous insufficiency during pregnancy, and discusses the possible role that some as yet uninvestigated mechanisms might have in it.
怀孕是静脉功能不全的一个危险因素。高达30%的女性在首次怀孕时会出现静脉功能不全，并且每一次后续怀孕其患病率都会更高。怀孕期静脉功能不全的病理生理学涉及多种病理生理机制。这些机制在孕期静脉功能不全病理生理学中的作用仍是一个讨论点。增大的子宫对盆腔静脉的机械压迫最初被认为是孕期发生静脉功能不全的原因。很快，人们发现孕期激素变化会导致静脉张力降低，并且这种降低被假定为静脉功能不全病理生理学中的一个主要因素。在大量后续研究中，这两种假说都经过了检验，得到证实或被否定，但尚未达成共识。本文综述了关于孕期静脉功能不全病理生理学的现有知识，并讨论了一些尚未研究的机制可能在其中发挥的作用。
