肾小球肾炎患儿的尿内皮素-1

Urinary endothelin-1 in children with glomerulonephritis.

作者信息

Tsau Y K, Chen C H

机构信息

Department of Pediatrics, National Taiwan University Hospital, Taipei, R.O.C.

出版信息

Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1998 Mar-Apr;39(2):86-8.

PMID:9599895

Abstract

Urinary endothelin-1 (ET-1) excretion was studied in 28 children with glomerulonephritis. Urinary ET-1 excretion was expressed as a ratio of urinary ET-1 to urinary creatinine (ET-1/Cr). There was a positive correlation between urinary ET-1/Cr and daily total urinary ET-1 in patients (r = 0.65, n = 32, p < 0.001). Urinary ET-1/Cr in children with glomerulonephritis and normal renal function was not different from that of normal controls. Urinary ET-1/Cr in glomerulonephritis children with ARF was lowest. These results showed that the pattern of urinary ET-1/Cr varied depending on the state of renal function in children with glomerulonephritis.

摘要

对28例肾小球肾炎患儿的尿内皮素-1（ET-1）排泄情况进行了研究。尿ET-1排泄量以尿ET-1与尿肌酐的比值（ET-1/Cr）表示。患者的尿ET-1/Cr与每日尿ET-1总量之间存在正相关（r = 0.65，n = 32，p < 0.001）。肾功能正常的肾小球肾炎患儿的尿ET-1/Cr与正常对照组无差异。急性肾衰竭（ARF）的肾小球肾炎患儿的尿ET-1/Cr最低。这些结果表明，肾小球肾炎患儿尿ET-1/Cr的模式因肾功能状态而异。