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[β受体阻滞剂在心血管系统疾病治疗应用中的现状与前景]

[The present status and prospects of therapeutic use of beta-blockers in diseases of the cardiovascular system].

作者信息

Kuzelová M, Svec P

机构信息

Katedra farmakológie a toxikológie Farmaceutickej fakulty Univerzity Komenského, Bratislava.

出版信息

Ceska Slov Farm. 1998 Feb;47(1):4-9.

PMID:9600149
Abstract

Beta-blockers are being revived as effective, safe, reasonably priced and well-tolerated drugs. Differences in the pharmacodynamic and pharmacokinetic properties of beta-blockers now make it possible to select for the therapy of the individual diseases from a wide range of available beta-blockers the most effective drug with the minimal undesirable effects. It is made possible by the progress in the development of this ATS group and particularly by the third generation of these compounds. A proof of the prospects of these drugs is provided by their extended indications as the first-choice drugs (myocardial infarction) as well as the generally extended possibilities of their therapeutic use (therapy of heart failure).

摘要

β受体阻滞剂正作为有效、安全、价格合理且耐受性良好的药物重新受到关注。β受体阻滞剂在药效学和药代动力学特性上的差异,使得从众多可用的β受体阻滞剂中为个体疾病治疗选择出疗效最佳且不良反应最小的药物成为可能。这得益于该类抗高血压药物研发的进展,尤其是第三代化合物的出现。这些药物的前景体现在其作为首选药物(心肌梗死)的适应证扩展,以及治疗用途总体上的扩大(心力衰竭治疗)。

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