β-咔啉类化合物对以伊博格碱为辨别刺激物训练的大鼠的影响。

The effects of beta-carbolines in rats trained with ibogaine as a discriminative stimulus.

作者信息

Helsley S, Rabin R A, Winter J C

机构信息

Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, USA.

出版信息

Eur J Pharmacol. 1998 Mar 19;345(2):139-43. doi: 10.1016/s0014-2999(98)00002-8.

DOI:10.1016/s0014-2999(98)00002-8

PMID:9600629

Abstract

The structural features and hallucinogenic properties shared by ibogaine and certain beta-carbolines prompted the evaluation of several representative beta-carbolines in rats trained with ibogaine as a discriminative stimulus. In a previous report from our laboratory harmaline completely substituted for ibogaine (83.5%). In the present study, only 6-methoxyharmalan completely substituted (86.3%). However, partial substitution was observed with harmine, harmane, harmalol, and tetrahydro-beta-carboline (THBC). Norharmane and 6,7-dimethoxy-4-ethyl-carboline-3-carboxylate (DMCM) failed to produce appreciable substitution. These results provide evidence for an ibogaine-like ether this extends to the previously reported anti-addictive effects of ibogaine remains to be established.

摘要

伊博格碱和某些β-咔啉共有的结构特征及致幻特性促使人们在以伊博格碱作为辨别刺激物进行训练的大鼠中对几种代表性的β-咔啉展开评估。在我们实验室之前的一份报告中，哈马灵完全替代了伊博格碱（83.5%）。在本研究中，只有6-甲氧基哈马灵完全替代了伊博格碱（86.3%）。然而，观察到哈明、哈尔满、去甲骆驼蓬碱和四氢-β-咔啉（THBC）出现了部分替代。去甲哈尔满和6,7-二甲氧基-4-乙基-咔啉-3-羧酸酯（DMCM）未能产生明显的替代作用。这些结果为一种类似伊博格碱的醚提供了证据，这种醚是否能延伸至先前报道的伊博格碱的抗成瘾作用仍有待确定。