Watanabe H, Numazawa M, Yamagata S
Tohoku J Exp Med. 1976 Jul;119(3):275-81. doi: 10.1620/tjem.119.275.
7,679 proctosigmoidoscopies were performed on 6,293 patients during a period from 1962 to 1974 at the Third Department of Internal Medicine, Tohoku University Hospital. Results were summarized as follows: Polyps were observed in 470 patients (7.5%) and cancer was found in 178 patients (2.8%). 129 patients (2.0%) were observed to have ulcerative colitis. There were 57 patients with melanosis coli, 12 radiation proctitis, 7 amebic colitis, 5 granulomatous colitis, 2 endometriosis coli, 2 carcinoid and 2 intestinal tuberculosis. Thus, 879 out of 6,293 patients examined had some forms of disease, an over-all incidence being 14.0%. Biopsies were performed under the proctosigmoidoscopic observation in 82.4% out of 273 patients with polyps during the 6-year period from 1969 to 1974 and 105 patients (46.7%) were observed to have adenomatous polyps. The age-specific distribution pattern and incidences of these patients with adenomatous polyps were mostly consistent with those of 178 patients with cancer of the large bowel, which were observed by proctosigmoidoscopy during the 13-year period from 1962 to 1974. Thus, it is suggested that etiological correlation exists between polyps of adenomatous type and cancer of the large bowel.
1962年至1974年期间，东北大学医院内科第三科室对6293名患者进行了7679次直肠乙状结肠镜检查。结果总结如下：470名患者（7.5%）观察到息肉，178名患者（2.8%）发现癌症。129名患者（2.0%）观察到患有溃疡性结肠炎。有57名结肠黑变病患者、12名放射性直肠炎患者、7名阿米巴结肠炎患者、5名肉芽肿性结肠炎患者、2名结肠子宫内膜异位症患者、2名类癌患者和2名肠结核患者。因此，在6293名接受检查的患者中，有879名患有某种疾病，总体发病率为14.0%。在1969年至1974年的6年期间，对273名息肉患者中的82.4%在直肠乙状结肠镜观察下进行了活检，其中105名患者（46.7%）观察到患有腺瘤性息肉。这些腺瘤性息肉患者的年龄特异性分布模式和发病率与1962年至1974年13年期间通过直肠乙状结肠镜检查观察到的178名大肠癌症患者的情况基本一致。因此，提示腺瘤性息肉与大肠癌症之间存在病因学关联。
