大鼠纹状体中自我刺激位点在纹小体/斑块中的优先定位。
Preferential localization of self-stimulation sites in striosomes/patches in the rat striatum.
作者信息
White N M, Hiroi N
机构信息
Department of Psychology, McGill University, 1205 Dr. Penfield Avenue, Montreal, Quebec, Canada H3A 1B1.
出版信息
Proc Natl Acad Sci U S A. 1998 May 26;95(11):6486-91. doi: 10.1073/pnas.95.11.6486.
Abstract
Histological sections of the mammalian striatum reveal a "matrix" that is histochemically distinguishable from patches, or "striosomes". The latter are cross sections of a compartment that consists primarily of tube-shaped structures radiating through the matrix. As a test of the hypothesis that the function of the striosome/patch compartment includes the mediation of behaviors related to reward, the present study examined electrical self-stimulation of the caudoputamen in rats with electrodes in either of the two compartments. Rats acquired and maintained bar-pressing responses that were contingent on stimulation through electrodes making contact with striosomes/patches more reliably than animals with electrodes terminating exclusively in the matrix. The results provide in vivo evidence that the striosome/patch compartment is functionally differentiated from the matrix compartment: Stimulation centered in or around the striosome/patch compartment but not in the matrix led to rapid acquisition of a new behavior.
摘要
哺乳动物纹状体的组织学切片显示出一种在组织化学上可与斑块或“纹状体小体”区分开的“基质”。后者是一个主要由穿过基质呈放射状排列的管状结构组成的隔室的横截面。作为对纹状体小体/斑块隔室的功能包括介导与奖励相关行为这一假设的检验，本研究用置于两个隔室中任一个的电极检查了大鼠尾壳核的电自我刺激。与电极仅终止于基质中的动物相比，大鼠通过与纹状体小体/斑块接触的电极进行刺激时，更可靠地获得并维持了依赖于刺激的压杆反应。结果提供了体内证据，表明纹状体小体/斑块隔室在功能上与基质隔室不同：集中在纹状体小体/斑块隔室内部或周围而非基质中的刺激导致新行为的快速习得。
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