Klar A J, Ivanova A V, Dalgaard J Z, Bonaduce M J, Grewal S I
National Cancer Institute-Frederick Cancer Research, Frederick, MD 21702-1201, USA.
Novartis Found Symp. 1998;214:87-99; discussion 99-103. doi: 10.1002/9780470515501.ch6.
Two epigenetic events at mat1, one of which is DNA strand specific, are required to initiate recombination during mating-type switching. The third, a chromosomally borne imprinted event at the mat2/3 interval regulates silencing and directionality of switching, and prohibits interchromosomal recombination. We speculate that the unit of inheritance in the mat2/3 interval is both DNA plus its associated chromatin structure. Such a control is likely to be essential in maintaining particular states of gene expression during development.
在交配型转换过程中启动重组需要mat1位点发生两个表观遗传事件，其中一个是DNA链特异性的。第三个事件是在mat2/3区间发生的染色体印记事件，它调控转换的沉默和方向性，并禁止染色体间重组。我们推测，mat2/3区间的遗传单位是DNA及其相关的染色质结构。这种控制在发育过程中维持特定的基因表达状态可能至关重要。
