Karrer S, Schäfer C B, Allgäuer M, Landthaler M
Dermatologische Klinik und Poliklinik, Universität Regensburg.
Dtsch Med Wochenschr. 1998 Apr 24;123(17):527-30. doi: 10.1055/s-2007-1024006.
A 50-year-old female patient underwent extirpation of a moderately differentiated, partially tubular ductal carcinoma of the left mamma and dissection of the left axilla followed by postoperative radiation therapy (total dose 58/48 gy). 2 weeks after the radiation therapy was stopped, treatment with goserelin subcutaneously was started. 6 weeks later numerous open and closed comedons appeared which were sharply confined to the radiation areas of left mamma and sternum.
DIAGNOSIS, TREATMENT AND COURSE: Because of the clinical diagnosis of acne comedonica following radiation therapy a local treatment with benzoyl-peroxide gel 5% and erythromycin cream 2% was performed, which led to improvement of the skin lesions within a few weeks and total restitution within 3 months. During one year no comedons have occurred although the local therapeutics are not applied constantly anymore.
Acne comedonica in the radiation area is a rarely known side effect of radiation therapy. Although the skin lesions cause no pain or itching they can affect the patient due to cosmetic changes. Local treatment with comedolytic acne therapeutics is effective.
一名50岁女性患者接受了左乳中分化部分管状导管癌切除术及左腋窝清扫术，术后进行放射治疗（总剂量58/48 Gy）。放疗结束2周后，开始皮下注射戈舍瑞林治疗。6周后，左乳和胸骨放疗区域出现大量开放性和闭合性粉刺，界限清晰。
诊断、治疗与病程：鉴于放疗后临床诊断为粉刺性痤疮，采用5%过氧化苯甲酰凝胶和2%红霉素乳膏进行局部治疗，数周内皮肤病变有所改善，3个月内完全恢复。尽管不再持续使用局部治疗药物，但在一年时间里未再出现粉刺。
放疗区域的粉刺性痤疮是一种鲜为人知的放疗副作用。虽然皮肤病变不会引起疼痛或瘙痒，但由于外观改变可能会影响患者。使用溶解粉刺的痤疮治疗药物进行局部治疗是有效的。
