Yamori Y, Horie R, Sato M, Fukase M
Stroke. 1976 Jul-Aug;4:385-9. doi: 10.1161/01.str.7.4.385.
Cerebrovascular ring-like fat deposition, which was noted only in hypertensive rats but never observed in normotensive rats even after they had been fed a high-fat cholesterol (HFC) diet for a long time, was successfully developed in the posterior communicating or other cerebrobasal arteries in normotensive rats fed an HFC diet for ten weeks after bilateral or unilateral carotid artery ligation or basilar artery ligation. These posterior communicating arteries with fat deposits were clearly dilated to a significant extent. These findings corroborated the fact that not only high blood pressure but also hemodynamic derangements induced by hypertension or other causes were important factors for the development of fat deposition in cerebral arteries.
脑血管环状脂肪沉积仅在高血压大鼠中被发现，而正常血压大鼠即使长期喂食高脂肪胆固醇（HFC）饮食也从未观察到这种情况。在双侧或单侧颈动脉结扎或基底动脉结扎后，对正常血压大鼠喂食HFC饮食十周，成功在其大脑后交通动脉或其他脑基底动脉中形成了这种脂肪沉积。这些有脂肪沉积的后交通动脉明显扩张到了显著程度。这些发现证实了不仅高血压，而且由高血压或其他原因引起的血流动力学紊乱都是脑动脉脂肪沉积发展的重要因素这一事实。
