The medical nucleus of the solitary tract mediates the trigeminally evoked pressor response.

The present study examined whether the nucleus of the solitary tract (NTS) plays a role in mediating the trigeminally evoked pressor response which occurs after noxious perturbation of the nasal mucosa or electrical stimulation of the ethmoidal nerve (EN5). We recorded arterial blood pressure responses to EN5 stimulations before and after injections of the calcium channel blocker CoCl2 into the NTS. Unilateral and bilateral injections of CoCl2 into the medial NTS resulted in significant blockade (p < 0.05 and p < 0.01, respectively) of the EN5-evoked pressor responses. Recovery of the pressor responses was observed 15-25 min after the CoCl2 injections. CoCl2 injections into the caudal commissural NTS remained largely ineffective with respect to blocking the EN5-evoked pressor responses. These findings strongly suggest that the medial NTS is a crucial link for the trigeminally induced pressor response.