Islam Syed Taufiqul, Sato Toshiya, Ohke Hanako, Shimatani Mari, Ishii Hisayoshi
Division of Physiology, Department of Oral Biology, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, Japan.
Division of Dental Anesthesiology, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, Japan.
J Physiol Sci. 2025 Jul;75(2):100028. doi: 10.1016/j.jphyss.2025.100028. Epub 2025 Jun 4.
Orofacial temperature influences orofacial functions and is related to hemodynamics mediated by the autonomic nerves. Although the properties of autonomic vasomotor responses differ in orofacial tissues, differences in the autonomic regulation of orofacial temperature are unclear. We examined the differences in blood flow (BF) and temperature (Tm) between the extraoral (lower lip) and intraoral tissues (tongue) of urethane-anesthetized rats. Noncholinergic parasympathetic vasodilation evoked by trigeminal-mediated reflex elicited significant increases in BF and Tm in both tissues, and these increases were larger in the tongue than in the lower lip. Activation of cervical sympathetic nerves significantly decreased BF and Tm in both tissues. These decreases were restored by parasympathetic reflex vasodilation; the effects were larger in the tongue than in the lower lip. Our results suggest that parasympathetic vasodilation is involved in the maintenance of BF and Tm, and that the effects may be greater in intraoral than in extraoral tissues.
口腔面部温度影响口腔面部功能，并与自主神经介导的血流动力学相关。尽管自主血管运动反应的特性在口腔面部组织中有所不同，但口腔面部温度的自主调节差异尚不清楚。我们研究了氨基甲酸乙酯麻醉大鼠的口外（下唇）和口内组织（舌头）之间的血流量（BF）和温度（Tm）差异。三叉神经介导的反射引起的非胆碱能副交感神经血管舒张导致两种组织的BF和Tm显著增加，且舌头的增加幅度大于下唇。颈交感神经的激活显著降低了两种组织的BF和Tm。这些降低通过副交感神经反射性血管舒张得以恢复；舌头的效果大于下唇。我们的结果表明，副交感神经血管舒张参与了BF和Tm的维持，且其在口内组织中的作用可能比口外组织更大。
