Mayer J
II. interní klinika FN, Brno Bohunice.
Vnitr Lek. 1997 Dec;43(12):809-14.
High-dosage chemotherapy is at present a very intensively investigated therapeutic procedure which rises great expectations. Administration of large doses of cytostatics is made possible by subsequent transplantation of autologous or allogenic haematopoietic progenitor cells (transplantation of peripheral stem cells or bone marrow). This reduces markedly the haematological toxicity of chemotherapy and it is possible to administer cytostatics in amounts at the non-haematological toxicity borderline. In the first part of the paper theoretical principles of high-dosage chemotherapy are analyzed, the relationship between the dosage of the drug and its effect. The author describes also cytostatics used in regimens of high dosage chemotherapy and discusses general toxic effects of this treatment.
高剂量化疗目前是一种正在深入研究的治疗方法，人们对其寄予厚望。通过随后移植自体或异体造血祖细胞（外周干细胞或骨髓移植），可以实现大剂量细胞抑制剂的给药。这显著降低了化疗的血液学毒性，并且能够以接近非血液学毒性边界的剂量给予细胞抑制剂。在本文的第一部分，分析了高剂量化疗的理论原理，即药物剂量与其效果之间的关系。作者还描述了高剂量化疗方案中使用的细胞抑制剂，并讨论了这种治疗的一般毒性作用。
