Sugimoto H, Tamura K, Fujii T
Department of Radiology, Jichi Medical School, 3311 Minamikawachi-machi, Kawachi-gun, Tochigi-ken, 329-04, Japan.
Eur Radiol. 1998;8(5):800-6. doi: 10.1007/s003300050475.
The objective of our study was to clarify the radiologic spectrum of disease entities belonging to the SAPHO syndrome (SAPHO being an acronym for synovitis, acne, pustulosis, hyperostosis, and osteitis). A retrospective analysis of radiologic data was undertaken to determine the relationship of the osteoarthritic changes seen in palmoplantar pustulosis (PPP, n = 179), acne (n = 3), psoriasis vulgaris (PsV, n = 355), generalized pustular psoriasis (GPP, n = 25), and chronic recurrent multifocal osteomyelitis (CRMO, n = 4). Osseous changes of PPP, acne, and CRMO overlap each other; 7 PPP, 2 acne, and 3 CRMO patients manifested stenocostoclavicular hyperostosis as well as hyperostosis of the spine, pelvis, and/or femur. These findings were not seen in either PsV or GPP patients. Thirteen PsV and 4 GPP patients had peripheral arthritis and/or symmetrical sacroiliitis, which were not observed in the PPP, acne, and CRMO patients. The PPP, acne, and CRMO patients may be grouped as belonging to the single disease entity, namely SAPHO syndrome. Our findings do not support the inclusion of PsV and GPP in the spectrum of this syndrome.
我们研究的目的是阐明属于SAPHO综合征（SAPHO是滑膜炎、痤疮、脓疱病、骨质增生和骨炎的首字母缩写）的疾病实体的放射学特征。对放射学数据进行回顾性分析，以确定掌跖脓疱病（PPP，n = 179）、痤疮（n = 3）、寻常型银屑病（PsV，n = 355）、泛发性脓疱型银屑病（GPP，n = 25）和慢性复发性多灶性骨髓炎（CRMO，n = 4）中所见骨关节炎改变之间的关系。PPP、痤疮和CRMO的骨质改变相互重叠；7例PPP、2例痤疮和3例CRMO患者表现为胸锁关节骨质增生以及脊柱、骨盆和/或股骨骨质增生。这些表现未见于PsV或GPP患者。13例PsV和4例GPP患者有外周关节炎和/或对称性骶髂关节炎，而PPP、痤疮和CRMO患者未观察到这些情况。PPP、痤疮和CRMO患者可归为单一疾病实体，即SAPHO综合征。我们的研究结果不支持将PsV和GPP纳入该综合征范围。
