Roy S, Liu H C, Loh H H
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Brain Res Mol Brain Res. 1998 May;56(1-2):281-3. doi: 10.1016/s0169-328x(98)00051-5.
The role of mu-opioid receptor in gastrointestinal transit was investigated using mu-opioid receptor knockout mice (MOR-KO). Our result establishes unequivocally that inhibition of GI transit by morphine is a mu-opioid receptor mediated function. In addition, we show that neither delta nor kappa receptor agonist given supraspinally or peripherally are able to inhibit GI transit in MOR-KO animals. It was interesting to observe that basal GI motility was lower in MOR-KO (-/-) compared to heterozygous (+/-) and wild type (+/+) animals.
利用μ-阿片受体基因敲除小鼠（MOR-KO）研究了μ-阿片受体在胃肠转运中的作用。我们的结果明确证实，吗啡对胃肠转运的抑制是一种由μ-阿片受体介导的功能。此外，我们还表明，无论是脊髓上还是外周给予δ或κ受体激动剂，均无法抑制MOR-KO动物的胃肠转运。有趣的是，观察到与杂合子（+/-）和野生型（+/+）动物相比，MOR-KO（-/-）动物的基础胃肠动力较低。
