Marotta P J, Roberts E A
Division of Gastroenterology and Nutrition, Hospital for Sick Children, Toronto, Ontario, Canada.
J Pediatr. 1998 May;132(5):894-7. doi: 10.1016/s0022-3476(98)70329-4.
Pemoline hepatotoxicity ranges from asymptomatic elevations in levels of serum aminotransferases to fulminant liver failure. We report five cases of pemoline hepatotoxicity in children (four boys, one girl), including the only reported case resulting in orthotopic liver transplantation. We conclude that pemoline causes toxic liver damage in children. The severity of the damage is highly variable, and its onset may be late in the course of treatment. Pemoline and methylphenidate may act synergistically to cause liver damage. The levels of serum aminotransferases should be monitored throughout treatment with these agents.
匹莫林肝毒性的范围从血清氨基转移酶水平无症状升高到暴发性肝衰竭。我们报告了5例儿童匹莫林肝毒性病例（4名男孩，1名女孩），其中包括唯一1例需要进行原位肝移植的报告病例。我们得出结论，匹莫林可导致儿童肝脏毒性损伤。损伤的严重程度差异很大，其发作可能在治疗过程后期出现。匹莫林和哌甲酯可能协同作用导致肝损伤。在使用这些药物的整个治疗过程中，应监测血清氨基转移酶水平。
