B细胞分化的转录调控

Transcriptional regulation of B-cell differentiation.

作者信息

Reya T, Grosschedl R

机构信息

Howard Hughes Medical Institute Department of Microbiology and Immunology, University of California, San Francisco 94143-0414, USA.

出版信息

Curr Opin Immunol. 1998 Apr;10(2):158-65. doi: 10.1016/s0952-7915(98)80244-6.

DOI:10.1016/s0952-7915(98)80244-6

PMID:9602304

Abstract

Transcription factors influence B cell differentiation by regulating the expression of numerous lineage-specific genes. Recent studies have identified factors that regulate differentiation of hematopoietic stem cells into B cell progenitors (PU.1 and lkaros), and further differentiation of these progenitors into mature B cells (NF kappa B, E2A, early B cell factor [EBF] and B cell specific activator protein [BSAP]). In addition, these studies demonstrate that complex interactions and redundancies among transcription factors safeguard the precise patterns of gene expression required for normal B cell differentiation.

摘要

转录因子通过调控众多谱系特异性基因的表达来影响B细胞分化。最近的研究已经鉴定出了一些因子，它们调控造血干细胞向B细胞祖细胞的分化（PU.1和Ikaros），以及这些祖细胞进一步分化为成熟B细胞（核因子κB、E2A、早期B细胞因子[EBF]和B细胞特异性激活蛋白[BSAP]）。此外，这些研究表明，转录因子之间复杂的相互作用和冗余性保障了正常B细胞分化所需的精确基因表达模式。