Zelger B G, Orchard G, Rudolph P, Zelger B
Department of Pathology, University of Innsbruck, Austria.
Histopathology. 1998 Apr;32(4):368-74. doi: 10.1046/j.1365-2559.1998.00396.x.
We describe nine cases of scalloped cell xanthogranuloma, a distinct solitary variant of non-Langerhans cell histiocytoses.
In this retrospective clinicopathological study scalloped cell xanthogranuloma mostly occurred on the back or head and neck of young adult males diagnosed as a xanthogranuloma, naevus, or basal cell carcinoma. Histology characteristically revealed a sheet-like infiltrate of predominantly scalloped histiocytes (> 79% of all cell types) in the upper dermis. Other mononuclear (vacuolated, xanthomatized, spindle-shaped, oncocytic) and multinucleate (foreign body, ground glass and Touton) histiocytes were also regularly seen. Immunohistochemically, all cases exhibited a macrophage/dendritic cell lineage positive with KP1 (CD68), KiM1p, HAM 56 and factor XIIIa. Ultrastructurally, numerous intracytoplasmic dense, occasionally also myeloid bodies were present. No associated systemic disease, hyperlipidaemia or recurrence were seen during follow-up.
These findings are similar to those of early lesions of xanthoma disseminatum: thus, scalloped cell xanthogranuloma could be regarded as a solitary counterpart of xanthoma disseminatum, and, moreover, fits neatly into a unifying concept of non-Langerhans cell histiocytoses.
我们描述了9例扇贝状细胞黄瘤，这是一种非朗格汉斯细胞组织细胞增生症的独特孤立性变体。
在这项回顾性临床病理研究中，扇贝状细胞黄瘤大多发生于年轻成年男性的背部或头颈部，诊断为黄瘤、痣或基底细胞癌。组织学特征显示，在上层真皮中主要为扇贝状组织细胞（占所有细胞类型的>79%）呈片状浸润。其他单核（空泡化、黄色瘤样、梭形、嗜酸性）和多核（异物型、毛玻璃样和图顿型）组织细胞也经常可见。免疫组化方面，所有病例均显示巨噬细胞/树突状细胞谱系对KP1（CD68）、KiM1p、HAM 56和因子ⅩⅢa呈阳性。超微结构上，可见大量胞浆内致密物，偶尔也有髓样小体。随访期间未见相关系统性疾病、高脂血症或复发。
这些发现与播散性黄瘤早期病变的发现相似：因此，扇贝状细胞黄瘤可被视为播散性黄瘤的孤立对应物，而且，很好地符合非朗格汉斯细胞组织细胞增生症的统一概念。
