Smith I, Saad R S
Keele University, Stoke-on-Trent.
Br J Anaesth. 1998 Feb;80(2):235-7. doi: 10.1093/bja/80.2.235.
The onset of action and intubating conditions after rocuronium 0.6 mg kg-1 or vecuronium 0.1 mg kg-1 were compared in a randomized, double-blind study when the timing of tracheal intubation was determined by clinical judgment alone. Times to laryngoscopy and completion of intubation were mean 89 (SD 20) s and 119 (28) s, respectively, in the rocuronium group compared with 110 (26) s and 142 (32) s in the vecuronium group (P < 0.05 in both cases). Recuronium also resulted in significantly better intubating conditions compared with vecuronium but with no significant reduction in the haemodynamic response to intubation. We found that onset of satisfactory intubating conditions after rocuronium was detected clinically, although even earlier intubation should be possible by careful timing or by neuromuscular monitoring.
在一项随机双盲研究中，当气管插管时机仅由临床判断决定时，比较了0.6 mg/kg罗库溴铵或0.1 mg/kg维库溴铵后的起效时间和插管条件。罗库溴铵组喉镜检查时间和插管完成时间分别平均为89（标准差20）秒和119（28）秒，而维库溴铵组分别为110（26）秒和142（32）秒（两种情况P均<0.05）。与维库溴铵相比，罗库溴铵还产生了明显更好的插管条件，但对插管的血流动力学反应没有显著降低。我们发现，罗库溴铵后临床可检测到满意插管条件的起效情况，尽管通过精确计时或神经肌肉监测甚至可以更早进行插管。
