七氟醚对兔肺传入活动的影响小于氟烷。

Sevoflurane has less effect than halothane on pulmonary afferent activity in the rabbit.

作者信息

Moores C, Davies A S, Dallak M

机构信息

University Department of Anaesthetics, Royal Infirmary of Edinburgh.

出版信息

Br J Anaesth. 1998 Feb;80(2):257-9. doi: 10.1093/bja/80.2.257.

DOI:10.1093/bja/80.2.257

PMID:9602600

Abstract

We have compared the effects of sevoflurane and halothane on the discharge frequencies of 19 slowly adapting and four rapidly adapting lung receptors in the rabbit by recording from single vagal fibres. Both agents reduced the discharge frequency of slowly adapting receptors during expiration (P < 0.0005), halothane having a greater effect than sevoflurane (P < 0.0005). Neither agent had any effect on discharge frequency at the end of inspiration when discharge frequency is at a maximum. Neither agent affected the discharge frequency of rapidly adapting receptors.

摘要

我们通过记录家兔单根迷走神经纤维，比较了七氟烷和氟烷对19个慢适应肺感受器和4个快适应肺感受器放电频率的影响。两种药物均降低了呼气期间慢适应感受器的放电频率（P<0.0005），氟烷的作用比七氟烷更大（P<0.0005）。当吸气末期放电频率达到最大值时，两种药物对其均无影响。两种药物均不影响快适应感受器的放电频率。