Bateman T A, Broz J J, Fleet M L, Simske S J
University of Colorado, Boulder 80309, USA.
Biomed Sci Instrum. 1997;34:374-9.
The effects of suspension on bone histomorphometry during the first and second week of tail suspension are compared for male and female mice of the common inbred strain, the C57BL/6J. In male mice, significant changes in bone formation rate (BFR) were largely confined to the endocortical perimeter. BFR along the endocortical mid-diaphysis in the femora of suspended male mice was reduced 54.1% and 55.6% for the first and second week, respectively. In female mice, however, measured metabolic changes due to suspension occurred along the periosteal perimeter, where there was a decrease in BFR of 58.3% for the first week and 60.9% for the second. The notable difference in the bone perimeter affected by suspension observed in male and female mice indicates a difference in the metabolic control of bone development in male and female C57BL/6J mice. More importantly, this may indicate a sex-based difference in preserving structural properties in the response of the skeleton to unloading.
对近交系C57BL/6J雄性和雌性小鼠在尾部悬吊第一周和第二周期间悬吊对骨组织形态计量学的影响进行了比较。在雄性小鼠中，骨形成率（BFR）的显著变化主要局限于皮质内周缘。悬吊雄性小鼠股骨皮质内中骨干处的BFR在第一周和第二周分别降低了54.1%和55.6%。然而，在雌性小鼠中，悬吊引起的代谢变化发生在骨膜周缘，第一周BFR下降了58.3%，第二周下降了60.9%。在雄性和雌性小鼠中观察到的受悬吊影响的骨周缘的显著差异表明，C57BL/6J雄性和雌性小鼠在骨发育的代谢控制方面存在差异。更重要的是，这可能表明在骨骼对卸载的反应中，在保持结构特性方面存在基于性别的差异。
