Integrin alpha1 localization in murine central and peripheral nervous system.

The distribution of neurons expressing integrin alpha1 subunit protein (INTalpha1) was examined in adult mouse tissues of not only the central nervous system, but also the sympathetic ganglia, and the adrenal gland by immunohistochemistry and immunoelectron microscopy. INTalpha1-positive neurons were observed in most tissues examined, and most of them were found to coexpress tyrosine hydroxylase (TH) except for Purkinje cells and hippocampal neurons. Expression of INTalpha1 was also observed in the malpositioned cortical neurons in reeler mutants, and appeared not to be affected by the aberrant cell migration of the reeler cortical neurons. In situ hybridization showed that the expression of INTalpha1 mRNA was correlated with synthesis of the INTalpha1 protein in each case, and this finding indicated that expression of the protein was controlled by transcriptional regulation of the INTalpha1 gene.